Biomedical subjects

I Tulić

Publications and source records attributed to I Tulić.

3 recordsLinked to original sources

PubMedDate not supplied

[Thyroid gland function during pregnancy].

In order to examine the thyroid gland function we analysed healthy pregnant women (20) with normal pregnancy course and term delivery, who had normal endocrinological findings before the investigated pregnancy. In all patients TSH, T4 and T3 concentrations were radioimmunologically determined by trimester, median values with standard deviations were analysed in order to establish normal values during gravidity, as well as the possible changes in relation to non-gravid condition. We determined that T4 (29.3%) and T3 (23.5%) concentrations significantly increased and that TSH insignificantly decreased (12.1%) in the first trimester of pregnancy. In healthy pregnant women during the advance of gestation there was a significant increase of T4 and T3, which was significantly higher in the following than in the previous trimester. TSH concentrations during pregnancy gradually decreased but the decrease during the whole course of pregnancy, and in separate trimesters, was not found to be statistically significant.

Female↗

PubMedDate not supplied

[Drug therapy of Graves' disease in pregnancy].

An analysis was made of 75 pregnant patients who received medicamentous therapy for Graves' disease before the investigated pregnancy and 20 healthy pregnant women with normal pregnancies and term delivery. A severe form of hyperthyreosis was found in 35 examined persons. A separate analysis was made of the patients who had no previous therapy (17) and pregnant patients who were treated with antithyroid drugs (18), with the aim to investigate their effect on the course and outcome of pregnancy and the condition of the newborn infant. In all examined pregnant women the median values with standard deviations for TSH, T4 and T3 in each trimester of pregnancy, the dynamics of their trends, as well as the correlation of values in treated and untreated pregnant women were recorded. The analysis of the pregnancy course in patients with hyperthyreosis indicated a significantly higher incidence of gestational diabetes and EPH gestoses (p less than 0.001). A separate analysis indicated that hyperthyreoidism is one of the risk factors in the occurrence of gestational diabetes. There were 90% of pregnant women who were delivered in an euthyroid condition achieved before pregnancy and maintained during pregnancy, 85% with mild and 77.1% with severe hyperthyreosis. The comparison of treated and untreated patients indicated that the percentage of delivered patients is similar (77.8:76.4), while the incidence of spontaneous abortions was higher (16.7:11.8) and of fetal deaths lower (5.5:11.8). There was one stillbirth in an untreated patient, while the remaining infants were healthy. The authors are of the opinion that it is necessary to achieve remission before pregnancy. In patients with severe hyperthyreosis the authors suggest the administration of antithyreoid drugs.

Female↗

PubMedDate not supplied

[Hematoma of the parametrium due to birth trauma].

From 1973 to 1980, assisting 59,068 vaginally completed deliveries, the authors encountered 19 hematomas of the parametrium (0.032%). Labour was prolonged in 13 out of these 19 cases and the instruments applied were the outlet forceps in 6 and the vacuum extractor in 2 cases, while the expulsion of the child in 5 cases was helped by an intravenous injection of Syntocin. Half the parturients were in the third and half in the fourth decade of their life; a third of them were primiparae. Clinically the picture of atony or uterine rupture prevailed. In the development of the hematoma of the parametrium a large number of etiological factors are to be pointed out: birth injury, parity, age, predisposition, and others. In 6 women subtotal hysterectomy, in 4 the ligature of the uterine artery, and in 5 the evacuation of the hematoma were applied, while in the remaining ones the treatment as conservative.

Adult↗