Biomedical subjects

I Ullrich

Publications and source records attributed to I Ullrich.

10 recordsLinked to original sources

PubMed2000

American College of Sports Medicine position stand. Exercise and type 2 diabetes.

Physical activity, including appropriate endurance and resistance training, is a major therapeutic modality for type 2 diabetes. Unfortunately, too often physical activity is an underutilized therapy. Favorable changes in glucose tolerance and insulin sensitivity usually deteriorate within 72 h of the last exercise session: consequently, regular physical activity is imperative to sustain glucose-lowering effects and improved insulin sensitivity. Individuals with type 2 diabetes should strive to achieve a minimum cumulative total of 1,000 kcal x wk(-1) from physical activities. Those with type 2 diabetes generally have a lower level of fitness (VO2max) than nondiabetic individuals. and therefore exercise intensity should be at a comfortable level (RPE 10-12) in the initial periods of training and should progress cautiously as tolerance for activity improves. Resistance training has the potential to improve muscle strength and endurance, enhance flexibility and body composition, decrease risk factors for cardiovascular disease, and result in improved glucose tolerance and insulin sensitivity. Modifications to exercise type and/or intensity may be necessary for those who have complications of diabetes. Individuals with type 2 diabetes may develop autonomic neuropathy, which affects the heart rate response to exercise, and as a result, ratings of perceived exertion rather than heart rate may need to be used for moderating intensity of physical activity. Although walking may be the most convenient low-impact mode, some persons, because of peripheral neuropathy and/or foot problems, may need to do non-weight-bearing activities. Outcome expectations may contribute significantly to motivation to begin and maintain an exercise program. Interventions designed to encourage adoption of an exercise regimen must be responsive to the individual's current stage of readiness and focus efforts on moving the individual through the various "stages of change."

Cardiovascular Diseases↗

PubMed1996

Resistance trained athletes using or not using anabolic steroids compared to runners: effects on cardiorespiratory variables, body composition, and plasma lipids.

OBJECTIVE: To determine whether there is a difference in cardiac size and function as well as in body composition, aerobic capacity, and blood lipids between resistance trained athletes who use anabolic steroids and those who do not, and to compare them to university cross country athletes. METHODS: Four groups of men were evaluated: recreational lifters, n = 11, lifting < 10 h.week-1; heavy lifters, n = 16, lifting > 10 h.week-1; steroid users, n = 8, same as heavy lifters and used steroids; runners, n = 8, university track members. Echocardiograms, body composition (hydrostatic weighing), maximum oxygen consumption (Vo2), and lipids were studied. RESULTS: As expected, Vo2 (ml.kg-1.min-1), was greatest in the runners, with no difference among the lifting groups. High density lipoprotein cholesterol in the steroid user group was lower than in heavy lifters or runners. Left ventricular internal diastolic dimension was similar among the groups. The left ventricular mass index of the steroid user group was significantly greater than recreational lifters, at 161 v 103. There was no difference among heavy lifters (127), runners (124), and steroid users. There was no compromise in diastolic function in any group. There were no differences among groups in resting or exercise blood pressure. CONCLUSIONS: Resistance training in the absence of steroid use results in the same positive effects on cardiac dimensions, diastolic function, and blood lipids as aerobic training.

Adolescent↗

PubMed1991

Osteoporosis.

Osteoporosis is an important medical condition which is expensive in morbidity and mortality. Type I osteoporosis affects women 10-15 years after menopause and involves primarily trabecular bone while Type II, senile osteoporosis, results in hip fractures in both sexes. Lifelong calcium intake and physical activity affect peak bone mass and are instrumental in prevention of osteoporosis. Therapy with fluoride, vitamin D, androgens and diphosphonates have been studied and their results and side effects are reviewed.

Aged↗

PubMed1988

The effect of three test meals on exercise tolerance of an individual with McArdle's disease.

This study examined the effect of three test meals on exercise tolerance of an individual with McArdle's disease, a myopathy characterized by phosphorylase b deficiency. The subject's exercise tolerance and ability to achieve the second wind, in response to each test meal, was evaluated over a 16-week period using a bicycle ergometer in a double-blind situation. Data were analyzed using one-way analysis of variance. No significant differences were found. It was concluded that a high protein meal, a high polyunsaturated fat meal, and a meal containing MCT oil did not affect the exercise tolerance of this individual compared to the control meal.

Adult↗

PubMed1985

Pyramidal tract deficits and polyneuropathy in hyperthyroidism, Combination clinically mimicking amyotrophic lateral sclerosis.

Generalized weakness, intermittent dysphagia, and a 40-pound weight loss developed in an elderly man over a six-month period. Examination revealed weakness, atrophy and fasciculations of extremity musculature, pseudobulbar speech, hyperactive upper extremity reflexes, and extensor toe signs without sensory loss. Results of electrodiagnostic studies were consistent with an axonal polyneuropathy. Endocrinologic results were compatible with hyperthyroidism. Radioiodine therapy resulted in resolution of clinical neurologic symptoms and signs within seven months. This case illustrates a previously undescribed concurrence of hyperthyroid associated polyneuropathy and pyramidal tract dysfunction that led to an initial clinical diagnosis of amyotrophic lateral sclerosis.

Aged↗

PubMed1984

Plasma and urinary 19-nor-deoxycorticosterone in 17 alpha-hydroxylase deficiency syndrome.

17 alpha-hydroxylase deficiency syndrome (17-OHDS) is associated with hypogonadism, hypertension, and hypokalemia. Aldosterone production, however, is not elevated, and therefore, other known or unknown mineralocorticoids must account for the excess in mineralocorticoid activity. This study sought to determine whether 19-nor-deoxycorticosterone (19-nor-DOC), a potent hypertensinogenic mineralocorticoid, was elevated in this syndrome. Plasma and urine from a young woman with 17-OHDS were examined from various corticosteroids before and after ACTH, dexamethasone, and cortisol administration. In the basal state, urinary and plasma 17-hydroxycorticosteroids were decreased, but 17-deoxycorticosteroids were extremely elevated, including corticosterone (B), 18-hydroxy-B (18-OH-B), tetrahydro-B (TH-B), TH-DOC, and 18-OH-TH-DOC. Basal urinary (UF) 19-nor-DOC measured by both high pressure liquid chromatography (4255 ng/day) and RIA [3800 ng/day; normal, 102 +/- 27 (+/- SD), was markedly elevated. UF 19-nor-DOC did not increase further after ACTH administration (4255 ng/day), but it decreased after both dexamethasone (less than 100 ng/day) and cortisol therapy (612 and 218 ng/day). Basal plasma 19-nor-DOC was elevated and increased after ACTH stimulation (366 pg/ml) and decreased during dexamethasone suppression (6 pg/ml). A plasma 19-nor-DOC precursor that converted to nor-DOC upon acidification (perhaps 19-oic-DOC) also was detectable (172 pg/ml). This study, therefore, demonstrates a marked elevation in UF 19-nor-DOC in 17-OHDS, which could account for some of the excess mineralocorticoid activity in this syndrome.

Adolescent↗

PubMed1978

Amenorrhea and edema.

In a 22 year old woman extensive edema developed during evaluation for amenorrhea. It was learned then that she was consuming escessive amounts of a laxative daily. Balance studies were performed which demonstrated that she excreted large amounts of sodium in her liquid stools while taking the dose of laxative she had been using. The presence of increased plasma renin activity and increased urinary aldosterone suggest that in this patient the occurrence of the edema after she discontinued use of the laxative was due to secondary aldosteronism presumably caused by plasma volume depletion.

Adult↗

PubMed1977

Nelson's syndrome: case report and review of the literature.

A patient who developed a pituitary tumor after adrenalectomy for Cushing's disease (Nelson's syndrome) is presented. The literature reviewed shows less than a 10 percent incidence of this disorder for which extremely elevated plasma ACTH levels are diagnostic. Special radiologic technics may be required to detect small pituitary tumors, but pituitary hormone levels may be elevated in the cerebrospinal fluid if there is suprasellar tumor extension. The different modalities available for treatment of Nelson's syndrome are discussed.

Adrenocorticotropic Hormone↗

PubMedDate not supplied

Gestational diabetes.

The complication of diabetes during pregnancy can be a disaster for both mother and child. However, proper management of diabetes prior to conception and during pregnancy has enabled diabetics to have normal infants nearly as often as non-diabetic women. This article reviews the historical aspects of gestational diabetes, the magnitude of the problem, carbohydrate metabolism during pregnancy, appropriate therapy, and offers some suggestions about how gestational diabetes and non-insulin dependent diabetes might be prevented.

Blood Glucose↗

PubMedDate not supplied

Soluble fiber: effect on carbohydrate and lipid metabolism.

Dietary fiber consumption has been associated with a decrease in diabetes and atherosclerotic diseases in population surveys. The contribution of soluble fiber (compared to insoluble fiber) to each of these problems has been investigated in several ways. This paper reviews the role which soluble fiber consumption plays in carbohydrate and lipid metabolism. The effects of specific fibers on glucose and insulin responses are examined; possible mechanisms responsible for the described effects are discussed. Epidemiologic evidence that consumption of foods containing soluble fiber contributes to decreased atherosclerotic disease is reviewed. Studies of administration of soluble fiber to hyperlipidemic males and females and normolipidemic subjects are examined with respect to changes in plasma lipids. Soluble fiber appears to play an important role in preventing and possibly treating diabetes and hyperlipidemia, diseases common to Westernized countries.

Carbohydrate Metabolism↗