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Biomedical subjects

I V Bagdasarova

Publications and source records attributed to I V Bagdasarova.

At least 19 recordsLinked to original sources
PubMed2003

[Expression of markers of immunocompetent cells, cytokine level, and L-arginine metabolism in complex extremely high frequency and interferon therapy of inflammatory diseases in women of highlands].

Chronic inflammatory gynecological diseases (CIGD) in highlanders (2,100-2,200 m a.s.l.) are accompanied with the following changes in immunoregulatory parameters: strengthening in the expression of CD3+ (TCR), CD4+ (T-helpers), CD16+ (NK-cells), CD25+ (activated IL-2R), increase in CD4+/CD8+ ratio, levels of circulating cytokines--alpha-, beta-, gamma-interferon (IFN) and alpha-, beta-tumor necrotizing factor (TNF), strengthening in immune adhesion of thrombocytes (IAT), and inhibition of the oxidative metabolic way of L-arginine with redistribution of the main metabolites formed via its non-oxidative way. Complex extremely high frequency (EHF) therapy and interferon (with Laferon) therapy of CIGD normalized expression of the differentiated and functional CD-markers of immunocompetent cells (ICC), CD4+/CD8+ ratio, increased expression of CD8+, decreased IAT and levels of circulating cytokines (IFN, TNF), changed L-arginine metabolism with activation of the oxidative way. Full-value of the population signs of immune stabilization due to the treatment was complemented with increase in the ICC functional parameters--markers of mitochondrial, lysosomal and mitotic activity. We first demonstrated a high effectiveness of complex use of EHF and Laferon as an immunocorrective therapy of CIGD in highlanders.

Adult↗
PubMed2001

Experimental clinical study of the effect of millimeter waves on microbial and inflammatory renal diseases.

An investigation is made of the effect of low-intensity millimeter waves on the development of acute and chronic pyelonephritis. It is shown that the application of millimeter waves diminishes the rate of pyelonephritis recurrence and reduces the probability of chronic pyelonephritis. Furthermore, these waves normalize lipid peroxidation, stimulate antioxidant protection, and improve blood rheology. Experimental investigations performed on animals provided evidence for the positive effect of millimeter waves on the morphofunctional state of organs and tissues as well as on blood circulation. This especially concerns pyelonephritis of mycoplasmic etiology.

Acute Disease↗
PubMed1991

[The morphofunctional characteristics of the blood lymphocytes in steroid-sensitive and steroid-resistant glomerulonephritis].

Morphofunctional properties of the lymphocyte suspension of patients susceptible and resistant to glucocorticoids in nephrotic form of glomerulonephritis were studied. Ultrastructural study of lymphocytes was performed as well as immune tests (the determination of lymphocyte glucocorticoid receptors number, proliferative activity of mononuclears, HIA genotypes) in 216 children. Morphofunctional insufficiency of the patient lymphocytes as compared to that in donors was established. A higher morphologic variety, functional sufficiency of lymphocytes, a higher number of glucocorticoid receptors and a preferable HIA genotype were found in the hormone-susceptible patients. Lymphocytes of hormone-resistant patients were characterized by a high activity of RNA-synthesizing apparatus, the presence of damaged organelles, low number of glucocorticoid receptors and by the failure of proliferative response to the dexamethasone test. These differences allow the differential approach to glucocorticoid therapy.

Adolescent↗
PubMed1991

[Problem of pathogenesis of Mycoplasma infection].

It has been shown that irrespective of the primary focus of affliction, M. hominis-induced infection should be regarded as a systemic disease characterized by an immune-mediated inflammation which is contributed to by blood kallikrein-kinin system activation resulting in changes in the coagulative system and fibrinolysis until disseminated intravascular coagulation develops. This allows one to interpret in a new fashion the etiology of some diseases proceeding with signs of vasculitis.

Animals↗
PubMed1991

[HB viral infection and the nephrotic syndrome].

Development, course and treatment of glomerulonephritis in comparison with other nephropathies was studied in 295 Hb-carriers with the nephrotic syndrome. Results of quantitative content of Hb-antigens in the blood serum and urine and nephrobiopsy materials were evaluated to show the etiopathogenetic role of Hb-viral infection in the development of glomerulonephritis. Four groups of Hb-carriers of the nephrotic syndrome were studied depending on hepatitis B markers in the blood serum. Treatment results are described in this category of patients.

Biomarkers↗
PubMed1989

[Determination of the sensitivity to glucocorticoids in vitro].

A modified method for the determination of glucocorticoid receptors in human lymphocytes is suggested. The principal distinction of the method is standardization by the lymphocyte count in a sample (1 mln) and the labeled hormone concentration. The modification saves time and money, limits the range of the data variations, and makes use of a lesser volume of blood. Examinations of 70 children aged 4 to 15 suffering from the nephrotic form of glomerulonephritis have made it possible to distinguish two groups of patients: with relatively high values of specific binding X = 6820.1 +/- 530.0 (n = 30, p = 0.95, t = 2.04), this corresponding to a clinical form of hormone-sensitive glomerulonephritis, and with relatively low values of specific binding X = 1815.2 +/- 302.8 (n = 40, p = 0.95, t = 1.96), that corresponds to hormone-resistant glomerulonephritis. Dynamic studies have not shown any statistically significant changes in the specific binding values. These results permit regarding the specific binding value as a prognostic criterion in the assessment of corticosteroid therapy; this allows a wide employment of the described method in practical nephrology.

Adolescent↗
PubMed1989

[Diagnostic possibilities of static gamma-scintigraphy using 99mTc pyrophosphate and Tc 99m phosphate in children with glomerulo nephritis].

Children with nephrotic glomerulonephritis were examined for incorporation of 99mTc-pyrophosphate and 99mTc-phosphone. The relationship was discovered between the accumulation of the radiopharmaceutical drug and the sensitivity to glucocorticoids used in the pathogenetic treatment. Accumulation of the drug in the course of the treatment documents the presence of complete, partial remission or the disease activity. It is recommended that static gammascintigraphy should be carried out for early assessment of the efficacy of the treatment and its correction.

Adolescent↗
PubMed1989

[Chemiluminescence of blood and urine in children with pyelonephritis and glomerulonephritis].

It was established during the study of blood serum and urine chemiluminescence in 57 children with pyelonephritis and in 38 children with glomerulonephritis that in the active disease stage, the intensity of overfaint luminescence rises as a result of lipid peroxidation (LPO) activation, accumulation of lipid hydroperoxides and oxygen-containing radicals. Four types of the kinetic curves of urine chemiluminescence were identified. They characterize the correlation between LPO activation and the level of antiradical defence in patients suffering from pyelo- and glomerulonephritis. The measurement of urine chemiluminescence in patients afflicted with pyelonephritis and glomerulonephritis may be one of the criteria for administering drugs possessing antiradical and antioxidant activity and can also be used in the control over the treatment efficacy.

Child↗
PubMed1989

[A mathematical model for predicting the efficacy of glucocorticoid therapy of glomerulonephritis].

A mathematical model is proposed for prediction of the efficacy of glucocorticoid therapy developed on the basis of the Bayes theorem and successive Wald's analysis. The model uses the retrospective values of the results of radioligand determination of the number of glucocorticoid receptor of lymphocytes and static renal scintigraphy. By means of the blind method the informative value of the mathematical model to predict the inefficacy of glucocorticoid therapy in nephrotic glomerulonephritis was 96%. A nomogram was developed.

Algorithms↗
PubMed1987

[Clinico-radiological assessment of the effectiveness of pathogenetic therapy in glomerulonephritis in children].

Liver scintigraphy and hepatobiliary scintigraphy were employed for the assessment of kidney and liver function in children with glomerulonephritis at the stages of pathogenetic therapy with chlorambucil and prednisolone. Noticeable disturbance of nephron and hepatocytic function at the climax of clinical manifestations of the nephrotic syndrome was established. The use of maximum and maintenance doses of prednisolone and chlorambucil resulted in significant improvement of clinical and radionuclide indices. However the effective renal plasma flow and the rate of passage of the radionuclide from the plasma into the proximal canalicular cell did not return to normal even in the catamnesis 1 year after the discontinuation of treatment in 35% of the patients with chronic glomerulonephritis. The use of maximum doses of cytostatics in 98.5% of the children produced no damaging effect on the hepatocyte, in 1.5% of the children the authors observed the development of drug hepatitis. Hypokinetic dyskinesia of the gall bladder was detected in the overwhelming majority of the patients therefore drugs improving bile secretion should be recommended as part of treatment.

Adolescent↗