[The Petersburg school of gynecologic oncology: some results and perspectives].
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Combined Modality Therapy↗
Biomedical subjects
I V Bokhman
Publications and source records attributed to I V Bokhman.
[Specifics of metabolic disorders in patients with "hormone-associated neoplastic" syndromes].
Overweight, lipidemia features, glucose tolerance and insulinemia were studied in 642 females suffering tumors of the corpus uteri, breast, ovary and large bowel, i.e. types of neoplasia which often occur and correspond to the syndrome of primary multiple "hormone-related" cancers. Beside certain obvious similarities in the said parameters established among patients with the said pathologies, the distinctions related, first of all, to degree of pernicious tumor process and, possibly, preoperative weight loss. Since no differences were found in manifestations of hormono-metabolic disturbances between cases of solitary and primary multiple neoplasms of the same localizations, it is suggested that carcinogenesis of both types might be caused by the same factors.
Adult↗
[Specifics of reproductive disorders and hormonal sensitivity of tumors in patients with "hormone-related neoplastic syndrome"].
Blood-serum levels of gonadotrophins and estradiol were assayed alongside with those of estradiol and progesterone receptors in the tissue of tumors of the breast, uterus, ovary and large bowel to establish general regularities of reproductive homeostasis in patients. The study was based on the assumption that risk of secondary tumor development is considerable in a patient who bears one of said malignancies. The effect of estrogen hormones was shown to be one of general causes of tumorigenesis. This is corroborated by enhanced hyperestrinism observed in cases of carcinoma of the corpus uteri as well as by certain data pointing to a reliable correlation between estrogen-stimulated synthesis of progesterone receptors and prognosis in patients with tumors of the breast, uterus and ovary. No estrogen dependence, however, was registered in patients with tumors of the bowel. Pathogenetic features shared by tumors of the large bowel and those of the reproductive system should probably be accounted for by disorders in metabolism.
Adult↗
[Parameters of estrogen expression in patients with endometrial tumors as prognostic signs of the effectiveness of neoadjuvant antitumor hormone therapy].
Comparison was made of changes in such morphological characteristics of tumor as cell differentiation and mitotic activity in 142 patients with endometrial carcinoma in the course of treatment, using tamoxifen or oxyprogesterone capronate or both, and those of estrogen background (karyopicnotic, eosinophilic and maturity indices, numerical index of maturity and blood-estradiol level). Three levels of estrogen background-low, medium and high-were identified by assay of the colpocytological indices in postmenopausal patients with endometrial carcinoma. Levels of the colpocytological indices observed at high indices of estrogen background proved a reliable numerical criterion for evaluating the sensitivity of the patients to neoadjuvant hormone therapy. A significant correlation was established between high estrogen background, pathogenetic variant I and high differentiation of tumor cells. The high incidence of hormonal pathology in tumor tissue was registered when the colpocytological indices dropped by half after oxyprogesterone capronate treatment, and by third-after combined therapy (tamoxifen + oxyprogesterone capronate). In cases free from pronounced pathomorphism, said indices dropped by not more than 20%.
17 alpha-Hydroxyprogesterone Caproate↗
[Radiation-induced multiple tumors].
Multiple primary tumors have been detected in 192 (5.0%) cases out of 3,812 patients with primary cervical malignancies, 100 (2.6%) cases having been traced to radiation-related origin. The peculiarities of the syndrome of radiation-induced multiple tumors of the rectum, vagina and corpus uteri, duration of their development, histological patterns, degree of cell differentiation, depth of invasion and patterns of metastasis spreading have been identified. Relative cumulative risk of secondary tumor development and causal factors have been established.
Female↗
[Minimal endometrial cancer and its detection in selective screening programs].
The study involved 1,256 cases of endometrial carcinoma. Minimal tumor (up to 2 cm in diameter, invasion- up to 0.5 cm) was diagnosed in 30%. This pattern showed a low potential for progression and metastasis spreading. Feasibility of identification of minimal cancer of the endometrium in the course of screening for hormone-dependent tumors of the reproductive system is discussed.
Endometrial Neoplasms↗