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Biomedical subjects

I V Brikman

Publications and source records attributed to I V Brikman.

13 recordsLinked to original sources
PubMedDate not supplied

Stimulation of penetrating corneal wound healing by exogenous fibronectin.

The paper describes the effect of exogenous fibronectin administered by instillation on the repair of the rabbit cornea after experimental mechanical injury. The effect was monitored by light microscopy and radioautography. Fibronectin had a beneficial effect on regenerating corneal epithelium, endothelium and keratocytes through a stimulatory effect on cell migration, proliferation and differentiation.

Administration, Topical↗
PubMedDate not supplied

[A new enriched balanced irrigation solution for intraocular surgery (experimental study)].

Experimental trials of a new intraocular irrigation solution, one of the enriched balanced salines, were carried out. A comprehensive morphologic study has revealed the protector characteristics of lactosol plus (lactosol + taurin) used in the management of irrigation injury to the posterior epithelium of the cornea in the course of experimental intrachamber perfusion. The protective properties of lactosol + taurin, a new enriched balanced saline, are explained by the similarity of its chemical composition to that of the intraocular fluid and by the presence of a stable polyfunctional bioprotector, taurin amino acid.

Animals↗
PubMedDate not supplied

[Effects of fibronectin instillation on reparative regeneration of the corneal tissue (an experimental study)].

Comprehensive morphologic studies (including light microscopy, morphometry, autoradiography) of experimental rabbits have revealed a stimulating effect of fibronectin instillations on healing of central penetrating wounds of the cornea. A polypotent mechanism of the stimulating effect of fibronectin instillations during all the stages of the reparative process in the corneal tissue was proved.

Animals↗
PubMedDate not supplied

[Cataract induction by products of lipid peroxidation].

Liposome suspension prepared from the unsaturated phospholipids exposed to lipid peroxidation (LPO) induced posterior subcapsular cataracts after injection into the posterior vitreous of rabbit eyes. In the background of this model lies a type of lens opacity formed during retinal degeneration when toxic peroxide substances diffuse anteriorly through the vitreous body resulting in vitreous opacities and complicated cataracts. Saturated liposomes (prepared from beta-oleoyl-gamma-palmitoyl) L-alpha-lecithin) did not induce lens opacities, which is the evidence that a lipid peroxidation mechanism may be responsible for the posterior cataracts. Along with cataract formation accumulation of LPO fluorescent products in vitreous, aqueous humor and lens was observed. It was followed by a decreased level of reduced glutathione in the lens. The obtained results strongly support the hypothesis of LPO initial role in cataracts.

Animals↗