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Biomedical subjects

I V Iarema

Publications and source records attributed to I V Iarema.

At least 19 recordsLinked to original sources
PubMed1999

[Method of medicamentous saturation of lymphatic system].

Data of experimental study in 18 mongrel dogs followed by clinical trial in 96 patients are represented, which concerns a method of indirect medicamentous saturation of lymphatic system, consisted in creation of medicamentous subcutaneous infiltration in the thighs followed by pneumocompression. Gentamycin contents in blood lymphatics and organs of experimental animals was studied in various periods of time. The obtained data have determined identity of the effect with the method of introduction of the antibiotics together with the media, which possess hyaluronidaze-like action, and followed by 2 hours duration phlebohypertension (by V.M.Buyanov, 1991). It promotes reduction of time for the procedure more than 3 times and gives possibility to avoid introduction of additional preparations, which are unnecessary load to the procedure. Gentamycin contents in blood serum of patients in various time intervals are demonstrated.

Adult↗
PubMed1998

[Prevention of errors and complications of laparoscopic cholecystectomy].

Great experience with performing laparoscopic cholecystectomies enabled the authors to work out a classification of failures, errors and complications appearing during preparation, in the process or after such operative interventions. Recommendations are given on prevention of them and for their less frequency.

Adolescent↗
PubMed1998

[Hemostatic therapy of gastroduodenal hemorrhage of non-ulcer genesis by the use of reserve mechanisms of hemostasis].

The article presents summarized results of treatment and examinations of 216 patients with gastro-intestinal bleedings due to acute errosive hemorrhagic gastritis and gastroduodenitis, cancer and polyposis of the stomach, liver cirrhosis and portal hypertension, hemorrhage against the background of atherosclerosis and arterial hypertension by administration of hemostatic medicine into the lymphatic system for activation and reinforcement of the reserve monocyte-macrophage mechanism of hemocoagulation. The results obtained confirm the expedience of this method of influencing the monocyte-macrophage hemostasis, having no complications and giving better medical effects.

Acute Disease↗
PubMed1998

[Endoscopic gastroduodenal lymphography with opacification in the diagnosis of penetrating ulcers].

The authors describe the method of endoscopic gastroduodenal lymphography with opacification and its results obtained after treatment of 79 patients with peptic ulcers. The method of diagnosing penetrating ulcers is thought to be highly informative and reliable. It should not be followed by repeated roentgenological examinations, so it decreases the X-ray load both on the patients and on medical personnel and allows the optimal methods of treatment of patients with chronic gastroduodenal ulcers to be chosen.

Adult↗
PubMed1998

[New methods for assessing the severity of endogenous intoxication in surgical patients].

New methods (a reticulocytic test, inhibition of erythrocyte sedimentation, registration of the frog's heart rate) were used in studying the toxicity of the serum, blood plasma and urine of surgical patients. The most informative methods for the assessment of the toxemia degree are thought to be the reticulocytic test and registration of the frog's heart rate. The maximum time for the determination of endotoxicity is 15 minutes. The pathological process severity can be estimated not only by the toxemia degree but also by its dynamics. The determination of endotoxicity is of value for choosing the methods for the individual detoxication therapy.

Acute Disease↗
PubMed1996

[Lymph transfusion in surgical care].

Scientifically grounded transfusion of lymph and its components was first used to treat 123 patients with severe surgical abnormality concurrent with secondary immunodeficiency, dysproteinemia and lipid deficiency. The treatment led to early improvement of the patients' general condition as shown up by normalized body temperatures, diminished intoxications events, reduced pus discharged from wounds, and early activation in patients. At the same time, the postoperative mortality rates decreased from 43 to 20.3%, the number of postoperative complications reduced from 18.2 to 13.4%, and their course abated. The patients' hospital stay reduced from 28.3 to 21.7 bed/days and the time of their disability dropped from 49.1 to 38.3 days.

Convalescence↗
PubMed1994

[Spermatic index of intoxication, a method of the assessment of blood toxicity].

The article deals with a new method for determining the degree of intoxication in patients with peritonitis of various etiology. Bull sperm cells were used as the test-object. The degree of intoxication is judged according to the ratio of the mean life time of the spermatozoa in the studied filtrate, obtained from the blood serum of patients with peritonitis by filtration through polysulfone membranes with a pass band of up to 70,000 daltons, to the life time in a control glucose-nitrate solution. The authors called this ratio as the spermatic index of toxicity. It was 80.1 +/- 18.7% in the donors. The spermatic index of toxicity was 35.0 +/- 9.0% in the first day after the operation, 44.6 +/- 16.7% on the fifth day, and 70.8 +/- 27.7% before discharge from the hospital. The method is automatic, which excludes subjective a appraisal of the results, and may be suggested for use in clinical practice.

Adolescent↗
PubMed1992

[Changes in lymph microcirculation in appendicular peritonitis].

When studied in experiment (63 dogs) and in clinical settings (116 patients), microlymphatic channel in appendicular peritonitis (AP) was found impaired, while lymphatic drainage of large-molecular substances and metabolites coming from the abdominal cavity appeared activated. Methods of correction of AP-induced abnormalities in microlymphocirculation have been developed which imply three levels of the impact: microcirculation, affected organ, lymphatic system. The clinical trial of the methods proved their efficacy even in the most severe AP forms.

Animals↗
PubMed1991

[Diagnosis and treatment of gastrointestinal hemorrhage].

The article analyses the results of treatment of 4,430 patients with gastrointestinal bleeding in the last four decades. Two periods, from 1950 to 1969 and from 1970 to 1990, are compared from the standpoint of change of the disease structure, the methods of diagnosis and hemostasis. The number of hemorrhages of ulcer genesis reduced from 80 to 40.3%. Changes in the pattern of the disease is associated with improved diagnostic methods and recognition of pathological processes which were previously inaccessible to radiological examination, such as the Mallory-Weiss syndrome, acute ulcerations of the mucosa. The age composition remains relatively stable. Just like in the previous years, each third patient is over 6.0 years of age. Despite introduction of new methods of treatment, such as endoscopic arrest of bleeding, enteral feeding, a new method for management of penetrating ulcers and others, the mortality rate reduced only from 4.5% (1950-1969) to 3.4% (1970-1990). It is noted, however, that fatal outcomes in the last years prevail among patients aged 65-70 or older.

Age Factors↗
PubMed1990

[Hemosorption and endolymphatic therapy in the treatment of paralytic ileus in peritonitis and acute intestinal obstruction].

Hemosorption and endolymphatic pharmacotherapy was included in the complex of treatment in 65 patients operated upon for spreaded forms of peritonitis and acute ileus. Hemosorption was performed within 12-24 h after operation, pharmacological agents (Aceclidine++, Cerucal, Obsidan) were introduced by antegrade endolymphatic infusions 4-6 h after hemosorption. The investigations have shown that in this case there rapidly appears intestinal peristalsis which is maintained not less than for 10-12 hours and in great part of patients it was completely recovered. Multiple stimulations by traditional methods were necessary in the control group to restore peristalsis. The combination of hemosorption and endolymphatic therapy may be recommended as an effective complex for the struggle against intestinal paresis in peritonitis and acute ileus in the postoperative period.

Acute Disease↗
PubMed1982

[Endolymphatic antibiotic administration in the combined treatment of peritonitis].

The endolymphatic method of infusion of antibiotics was used in 165 patients with acute inflammatory diseases of organs of the abdominal cavity, 84,8% of them recovered. A single endolymphatic infusion of a usual dose of the antibiotic makes a very high concentration of the drug in the lymphatic system and maintains a therapeutic concentration of the antibiotic in the lymph during a day. In the lymphatic nodes it retains for more than 2 weeks. The methods reduces acute inflammatory processes, makes the temperature and blood leukocytes normal and improves the general state of the patients resulting in their quicker recovery. The endolymphatic therapy with antibiotics is in good agreement with surgical and other conservative methods of treatment.

Adult↗
PubMed1980

[Experimental study of a new method of endolymphatic antibiotic administration and a trial of its clinical use].

A new procedure for antibiotic administration via endolymphatic route was developed. Experiments performed on 34 dogs revealed differences in the pharmacokinetics of gentamicin in the central lymph after its administration in a dose of 4 mg/kg via endolymphatic and intramuscular routes: the maximum levels of 590 and 23 mg/kg were determined in 15 and 45 minutes respectively. In 1 hour the concentrations decreased to 17 and 10 mg/kg. When gentamicin was administered endolymphatically it remained in the lymph and blood in concentrations of 0.2 and 0.8 mg/kg respectively for 24 hours. The kinetics of gentamicin in the blood serum within the first 6 hours after its administration by both routes did not differ significantly. After endolymphatic administration high concentrations of gentamicin (56-36 mg/g) were determined in the paraaortal and retroperitoneal lymph nodes in 10-24 hours. Within the period of the 4th to the 13th day its concentrations of at least 5 mg/g were detected. The changes in the structure of the lymph nodes observed 18-48 hours after the antibiotic endolymphatic administration were reversible and returned to normal by the 96th hour. The first experience with the clinical use of the endolymphatic route of gentamicin administration showed its high efficacy in 84.8% of the patients with severe purulent inflammatory diseases of the organs of the abdominal cavity. The antibiotic was used in a dose of 80 mg once a day. The treatment course consisted of 5-6 infusions. Perspectives of the further experimental and clinical investigation of the procedure are indicated. Endolymphatic administration of antibiotics makes it possible to increase the efficacy of antibiotic therapy of a number of severe inflammatory infections.

Adult↗
PubMed1980

[Kanamycin sulfate pharmacokinetics in the lymph and blood in complicated acute inflammatory diseases of the abdominal cavity organs].

Pharmacokinetics of kanamycin sulfate in the lymph, blood and urine of 12 patients with acute inflammatory diseases of the organs of the abdominal cavity was studied. The study showed that kanamycin sulfate administered intramuscularly was rapidly absorbed into the lymph and blood reaching the maximum levels within 2 hours of the administration. The therapeutic levels were preserved for at least 8 hours. The concentration of kanamycin in pure lymph by the method of lymphosorption was 20 per cent lower which was connected with the drug adsorption by the sorbents.

Abdomen, Acute↗