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I V Kozlova

Publications and source records attributed to I V Kozlova.

7 recordsLinked to original sources
PubMed2000

[Apudocytes and mast cells in chronic inflammation of colon: clinicomorphological correlations].

AIM: To study functional morphology of a total population of endocrine cells of colon mucosa, mast and enterochromaffine cells. MATERIALS AND METHODS: Light and electrone microscopy, immunohistochemical methods, morphometry were used to study endocrine and mast cells of the sigmoid colon in inflammation. RESULTS: Changes of functional morphology and size of endocrine and mast cell population as well as apudocytes producing serotonin, melatonin, vasointestinal peptides were stated. Apudocyte and mass cell functional morphology, clinical symptoms and mucosal structural changes correlated. Specificity of some parameters in Chron's disease is shown. CONCLUSION: The results may provide additional criteria in diagnosis of different variants of chronic colitis.

APUD Cells↗
PubMed1999

[Changes in the APUD system of the large intestine as a risk factor for colorectal cancer].

A common population of endocrine cells, apudocytes producing serotonin, melatonin, vaso-intestinal peptides and mast cells were examined on unaffected mucous membranes of 27 colorectal cancer patients. Light and electron microscopy, immunohistochemical and morphometric methods were used. A marked decrease in total number of apudocytes, hypoplasia of cells producing serotonin, melatonin, vaso-intestinal peptides were revealed at early stages of cancer irrespective of the tumor structure. Mast cells in premetastatic period outnumbered those after emergence of metastases. The results obtained may serve as additional criteria of early colorectal cancer diagnosis.

APUD Cells↗
PubMedDate not supplied

[The geographical distribution of genetic variants of the tick-borne encephalitis virus].

Geographic distribution of 185 tick-borne encephalitis (TBE) virus strains isolated in 8 physico-geographic areas and classified into six genetic variants was analysed. The strains of genetic variant I homologous to the Sophyin prototype strain were found to occur predominantly in the Far East and also frequently found in Western and North-Western parts of the East European plain. The vast territories from lake Baikal in the East to Ukraine in the West harbor mostly the strains significantly different from the Far-Eastern Sophyin strain. Hybridization experiments with oligonucleotide probes specific for the Neudorffle strain showed that the strains genetically similar to the virus of central European encephalitis occurred also in Eastern Europe and Western Siberia. It is concluded that a relationship exists between genetic types of TBE virus and their geographic origin.

Animals↗
PubMedDate not supplied

[Clinical observation periods for diphyllobothriasis patients depending on the invasion period].

Discrepancy between the terms of clinical observation and normalization of gastric functions was established on the basis of a time-course study of gastric secretory function in 189 diphylobothriasis patients examined before the treatment and 1-2, 5-6, 10-12 months after it. Recovery of the secretory function took less than 5-6 months in people recovered from short-term invasion (less than a year), while in patients recovered from long-term invasion (lasting more than a year) it took 10-12 months, and reduced secretory activity in the latter group was still observed in many cases 10-12 months after treatment. Results of the study may be used in optimization of terms and forms of clinical observation.

Adolescent↗