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Biomedical subjects

I V Lukashova

Publications and source records attributed to I V Lukashova.

4 recordsLinked to original sources

[Study of human lymphocyte proteins using two-dimensional electrophoresis].

Using O'Farrell 2DE modified method, a panel of human lymphocyte proteins have been studied. A 2-D map involving 273 fractions characterized in M(r)/pI coordinates has been developed. Some proteins were identified on the map and some comparability of experimental results to the Celis et al. data demonstrated. Ten protein fractions displaying some variability in a sample of 30 patients were revealed. A change in the amount of the E2 fraction M(r)/pI -51.0/5.70 was found among patients with chromosome 5 short arm deletion and translocation.

Blood Proteins↗

[Two-dimensional electrophoresis of myocardial proteins in human cardio-vascular diseases].

The protein composition of human myocardium at some cardiovascular pathologies was studied by use of 2D electrophoresis. It was found that dilitation(al) cardiomyopathy and ischemia are both characterized by transferrin accumulation in myocardium and by enhanced expression of a protein with Mm 3 kD/pI 5. Besides that, at ischemic disease there was seen an elevation of the fetal isoform in the light chain of myosin. For one of the polymorphous protein systems, the occurrence rate changes were also recorded.

Adult↗