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Biomedical subjects

I V Shcherbakova

Publications and source records attributed to I V Shcherbakova.

3 recordsLinked to original sources

[Laser spatial scanning in flow cytometry].

The main flow laser cytometry principles, based on the elastic light scattering, spheres of its applications, problems of its realization and utilization in the immunological investigations and diagnostics are analysed. The experimental model of a flow cytometer with laser probing beam space scanning, originally proposed by the authors, is described. The apparatus was tested by polystyrene latex spheres and biological objects. The experiments showed that the achieved sensitivity was enough to register red blood cells, their complexes and bacterial cells.

Flow Cytometry↗

[Activation of kallikrein-kinin system, degranulating activity of neutrophils and blood-brain barrier in schizophrenia].

To evaluate permeability of blood-brain barrier (BBB) some immunological and biochemical indices were used. The levels of the activity of serum kallikrein-kinin system (KKS), compliment system, C-reactive protein (CRP) concentration, blood inhibitory potential, metabolic and degranulating activities of neutrophils, as well as functional activity of leukocytic elastase were investigated in 30 patients. Acute schizophrenic attack was accompanied by both activation of KKS and by the increase of functional activity of alfa-1-proteinase inhibitor. The increase of CRP levels, high hemolytic activity of complement as well as considerable degranulating activity of polymorphonuclear leukocytes may be the causes of the damage of BBB permeability during acute schizophrenic attack.

Acute Disease↗