[Detoxification in the complex treatment of patients with acute cholecystitis].
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Biomedical subjects
Publications and source records attributed to I V Sinitsyn.
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A prolonged infusion of noradrenaline (40 mkg) into the mesenterial artery was carried out in the early postoperative period in 30 patients with diffuse purulent peritonitis in order to arrest the inflammatory reaction of the peritoneum. More rapid decrease of intoxication, prevention of plasmatic losses and less lethality were noted as compared with the control group.
An analysis of 127 case histories of patients with diffuse peritonitis treated in the clinic during 1979-1982 has been made. But for all the complex intensive treatment, generalization of the inflammatory process in the abdominal cavity has been shown to cause high mortality rate (76%). The patients' age substantially aggravated the prognosis. 79% of the victims were older than 60. In 56,6% of cases the development of peritonitis had different complications, 11% needed relaparotomy to treat the complications. Late diagnosis of the disease was specifically responsible for unsatisfactory results--two thirds of the patients had toxic or terminal stages of the disease.
On the basis of examination of microcirculation by the method of contact microscopy and evaluation of the survival rate of rats with experimental peritonitis the authors have shown a positive effect (reduced lethality) of the intraperitoneal administration of noradrenaline at the expense of reduced capillary blood flow and reduced intoxication.