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I V Timoshenko

Publications and source records attributed to I V Timoshenko.

4 recordsLinked to original sources
PubMed1980

[Experimental models of embryonic nephroblastomas (Wilms' tumor)].

Histological structure and histochemical characteristics of renal tumours induced in rats either by N-nitrosodimethylamine (DMNA) or N-nitrosoethylurea (NEU) are described. The rats treated with oral administration of DMNA developed 1 nephroblastoma and 176 mesenchymal tumours similar to mesoblastic nephroma. In rats receiving the transplacental treatment with NEU 24 mesenchymal tumours and 5 nephroblastomas corresponding to the epithelial variant of human Wilms' tumour occurred. Histologic and histochemical findings show that the mesenchymal neoplasms contain the epithelial component in the form of preexisting renal tubules. These tubules are similar to those of the normal kidney and strongly differ from the primitive tubular structures of embryonic rat kidneys and nephroblastomas.

Animals↗
PubMed1980

Nephroblastoma and renal mesenchymal tumor induced in rats by N-nitrosoethyl- and N-nitrosomethylurea.

Rats treated prenatally with N-nitrosoethylurea or with N-nitrosomethylurea developed nephroblastomas, renal mesenchymal tumors and epithelial tumors (adenomas and carcinomas) of the kidneys. 15 nephroblastomas and 59 mesenchymal tumors were examined histologically. Nephroblastomas were encapsulated growths composed of dark cells, forming primitive tubules similar to those seen in the rat embryonal kidney and in human Wilms' tumor. Mesenchymal renal tumors showed an infiltrative growth and consisted of fibroblast-like cells, smooth muscles and angiomatous areas with the engulfed pre-existing tubules. These growths are similar to the mesenchymal renal tumors induced in the rat by N-nitrosodimethylamine. Nephroblastoma and mesenchymal renal tumor are considered to be separated entities, the first corresponsing to the epithelial variant of human Wilms' tumor and the second to congenital mesoblastic nephroma.

Animals↗