Biomedical subjects

I V Zabolotskaia

Publications and source records attributed to I V Zabolotskaia.

4 recordsLinked to original sources

PubMed1999

[The effects of space flights on the lipid composition of blood, adrenal glands and liver in rats].

Numerous postflight biochemical and morphological investigations of rats evidenced some shifts in lipid metabolism due to weightlessness and/or gravitation stresses. In the "Spacelab-2" experiment with rats, lipid spectra of blood serum (plasma), liver and adrenal glands were explored with the thin layer silicagel chromatography with the aim of evaluating stress effects of space flight on lipid metabolism. For the first time tissues were gathered and analyzed on day 13 in microgravity. Lipid composition of the liver remained unchanged after 13 days of flight. Those were cholesterol ethers of blood serum that were significantly increased while no changes had occurred in the relative quantities of each class of lipids in their totality. The adrenal glands considerably reduced concentrations of total lipids, free cholesterols, triglycerides, and free fatty acids. Within four hours into landing, free fatty acids were found to increase in blood plasma whereas the relative content of triglycerides decreased. Hepatic lipids remained unchanged and the adrenal ones did not differ from the control. On day 14 of recovery, the total content of blood plasma lipids was significantly increased on the score of triglycerides, and free and esterified cholesterols. The liver displayed decreases in all classes of fats; however, similar changes were in the control rats, too. The lipid composition of the adrenal did not differ from that of control. According to the total balance of lipids in rats' blood serum and liver, no signs of acute or chronic stress had been developed by the concluding stage of the 140-day space mission. Yet, one cannot exclude an acute stress early in mission that might have been the cause for the shifts in lipid metabolism in adrenals resulting in their reversible delipoidization.

Adrenal Glands↗

PubMed1997

[Use of bicycle ergometry test for studying metabolism in women during long-term hypokinesia].

Studies performed under conditions of a 120-day HDT in the female human subjects demonstrated that out of 20 biochemical parameters of the blood characterizing the carbohydrate and lipid exchange only 14 indices changed significantly during hypokinesia. As this takes place, the maximum number of changes was revealed with the help of the graded physical load test (GPL-test) and only in case of 9 indices the alterations were found at rest. Physical loads which have been used during HDT as the preventive measures had no effect only on insignificant part of metabolic shifts such as hypokinesia-associated increase of an activity of blood lactate dehydrogenase and relative content of phosphatidylcholine as well as an increased blood content of phosphates and decreased relative portion of phospholipids which also revealed with the aid of GPL-test. All other changes which have been revealed in HDT both at rest (increased blood level of triglycerides, lactate, relative content of free fatty acids, free cholesterine and sphingomyelin with augmented decrease in glucose concentration) as well as with the help of GPT-test (an increase of absolute blood content of free fatty acids with a decrease in their relative content; an increase of the relative content of total cholesterine with decreased portion of cholesterine ethers) have been stopped.

Blood Glucose↗

PubMedDate not supplied

[Characteristics of cosmonauts' metabolism after extended missions on the international space station].

In eight Russian members of the ISS crews 1 to 5 enzymes and some other metabolites were analyzed in blood in the pre- launch period, on the landing day, and on days 6-8 and 14-19 of recovery. Deviations in the biochemical parameters were typically within the physiological norm without clinical implications. Biochemical deviations on the landing day seemed to relate to metabolic shifts due to long-term microgravity and, on the other hand, were a reaction to acute gravitational stress on return to 1 g. Dynamics of a number of parameters was markedly different as compared with the data from cosmonauts who had made long missions to the Mir space station, but this can be attributed to different g-profiles during descent and blood sampling schedule. In two to three wks the parameters regained normal values suggesting that negative effects of readaptation to the Earth's gravity were fully remedied.

Adaptation, Physiological↗

PubMedDate not supplied

[Basic biochemical blood parameters in astronauts in preflight training].

From the findings of biochemical blood analyses obtained during original examinations of 24 cosmonauts with a repeat blood sampling (2-5 times) of each test subject there calculated the mean values of norm and the interval limits of norm using 33 biochemical blood indices for a given group of test subjects. It is shown that in the absence of significant discrepancies from the generally used mean population standards for the cosmonauts it is typical of some specific differences from universally adopted standards of the parameters mainly related to energy metabolism.

Blood Chemical Analysis↗