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Biomedical subjects

I Vogt-Moykopf

Publications and source records attributed to I Vogt-Moykopf.

10 recordsLinked to original sources
PubMed1979

Ventilation studies with krypton-81m.

Nuclear medicine offers well-established methods for regional lung function assessment in the preoperative evaluation of patients with lung disease. The perfusion study with Tc-99m macroaggregates is simple and can be performed without special precautions in radiation shielding. The ventilation study with Xe-133, however, requires more elaborate apparatus as well as special procedures to collect the exhaled radioactive rare gas. Nuclear medicine departments with access to short-lived radionuclides from a nearby cyclotron can use the krypton isotope Kr-81m. The physical half-life of Kr-81m is 13 s. Its gamma energy of 190 keV is optimal for gamma cameras. Kr-81m can be used as a medical isotope in spite of its short half-life. It can be eluted with a continuously flowing gas from the generator containing the mother nuclide Rb-81 which has half-life of 4.6 h. This short half-life not only simplifies radiation protection but allows repeated studies in different projections as well. Examples of comparative studies with Xe-133 and Kr-81m are presented. The importance of taking not only anterior and posterior pictures but also lateral oblique views is stressed.

Half-Life↗
PubMed1979

[Clinical relevance of 111In-bleomycine in intrathoracal neoplasms (author's transl)].

With a medium storage ratio of 1:1.4 between sound and neoplastic lung tissue additional diagnostic information cannot be obtained by positive tumor scintigraphy with 111In-bleomycine. This may be accounted for on the one hand by the diffuse borders of the storage foci, on the other hand by the relatively high storage of radioactivity in normal lung tissue.

Aged↗
PubMed1978

[Resistance testing and chemotherapy results of bronchial tumours (author's transl)].

In a pilot study of 40 patients with inoperable bronchiogenic carcinomas the results of clinical therapy were compared with those of in vitro tests by measuring the effects of cytostatic agents on the incorporation of precursors into DNA and RNA in tumour cells incubated in vitro for short periods. Tumour cells that showed little inhibition by the cytostatic agents in vitro (less than 30% inhibition at a concentration of 10(-2) mg/ml adriamycin) came from patients who responded poorly to cytostatic therapy. On the other hand, tumour cells that were strongly inhibited in vitro (greater than 30% inhibition) came from tumours which proved to be sensitive to the chemotherapy given to the patient. A strong correlation existed between the inhibition of uridine incorporation by the tumour cells in vitro by adriamycin and the responses of the tumour to clinical therapy even when combination-therapy was given without adriamycin. There was also a significant correlation between the inhibiting effect of adriamycin in vitro and the survival time of the tumour patients.

Bronchial Neoplasms↗
PubMed1978

[The transmediastinal pleurotomy (author's transl)].

A new surgical method is presented, the transmediastinal pleurotomy. With this technique it is possible to explore the opposite lung from a standard thoracotomy and to perform diagnostic or therapeutic resections in suitable cases. So far we have performed 20 transmediastinal pleurotomies without any complications.

Humans↗
PubMed1977

[Clinical aspects of bronchial cancer].

The most frequent cause of death of the male is cancer of the lungs. The prognosis is still unfavourable. The cases of patients having survived for 5 years amount altogether to not more than 5%, as far as operated patients are concerned, the quota amounts to 20-25%; in cases of early detection of cancer, however, the rates are up to 40%. Precaution and preventive care (reduction of cigarette consumption) is at present not possible. Considerable time is being wasted because of the uncharacteristic and gradually proceeding symptoms and misinterpretations of the X-ray findings. The bronchial carcinoma can imitate any other disease of the lungs. Even a normal X-ray picture does not exclude carcinoma. The observation of acute symptoms appearing for the first time and of those already existing, but changing suddenly, is essential. Exclusive treatments are dangerous. Any X-ray finding of the lungs should be followed up to all bronchological details. A "normal" X-ray picture, accompanied by clinical symptoms, requires basic diagnostic measures including bronchoscopy.

Aged↗
PubMed1976

[Palliative surgery in bronchial carcinoma and surgery for metastases (author's transl)].

Report on 54 patients with bronchial carcinoma, where a primary palliative resection of the tumor has to be done. Indications were central abscess of the carcinoma, bleeding of the tumor by arrosion, pain because of infiltration of chestwall, patient's demand on operation. Beneath lobectomy and pneumonectomy parietal pleurectomy, exstirpation of subclavian lymphnodes of the carcinoma and endobronchial resections of the tumor were done. In addition from 1970 to 1975 on 61 patients 66 resections of pulmonary metastasis were done. Surgical therapy of coin lesions without long preoperative surveillance is mandatory.

Abscess↗