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I W Abrahams

Publications and source records attributed to I W Abrahams.

14 recordsLinked to original sources
PubMed1991

Association of HLA antigens with Vogt-Koyanagi-Harada syndrome in a Han Chinese population.

Vogt-Koyanagi-Harada syndrome, or the uveomeningitis syndrome, is one of the most commonly identified types of endogenous uveitis diagnosed in China. Because its incidence is higher in Orientals than in whites, immunogenetic background [corrected] may be an important factor in its incidence. We performed HLA-A, -B, and -DR typing on 25 patients with Vogt-Koyanagi-Harada syndrome and on 65 healthy control subjects from the Han Chinese population. The results showed that HLA-DR4 and -Dw53 were closely associated with Vogt-Koyanagi-Harada syndrome (P less than .001 [relative risk = 16.0] and P less than .001 [relative risk = 34.2], respectively). This association is similar to that reported in patients with Vogt-Koyanagi-Harada syndrome in Japan, suggesting that DR4 and DRw53 may play important roles in the development of Vogt-Koyanagi-Harada syndrome in Oriental populations.

Adolescent↗
PubMed1989

Propionibacterium acnes endophthalmitis: an unusual manner of presentation.

An unusual clinical presentation of Propionibacterium acnes endophthalmitis as a solitary nodule on the corneal endothelial surface at the superior limbus in association with granulomatous uveitis is reported. The patient had previous extracapsular cataract surgery with intraocular lens implantation and two subsequent YAG laser capsulotomies. The organism was grown from a microbiopsy of the nodule after a negative anterior chamber tap. The patient was treated with systemic antibiotics, his condition worsened, and the implant, lens capsule, and anterior vitreous were surgically removed. No additional organisms were found and there was no evidence of coexistent phacoanaphylaxis. The patient had no further inflammation and attained 20/25 aphakic vision.

Anaphylaxis↗
PubMed1987

Phakoanaphylaxis as a cause of granulomatous uveitis following extracapsular cataract surgery.

Phakoanaphylaxis following modern extracapsular cataract surgery presents as a progressively severe granulomatous uveitis months after surgery. Two patients who developed pathologically confirmed phakoanaphylaxis following extracapsular surgery with posterior intraocular-lens insertion are presented. The evolution of the clinical picture is described, and the successful surgical therapy in each case is presented. It is important to recognize this cause of granulomatous uveitis for successful management of the problem.

Aged↗
PubMed1985

Diagnosis and surgical management of phacoanaphylactic uveitis following extracapsular cataract extraction with intraocular lens implantation.

One year after a successful extracapsular cataract extraction with posterior chamber lens implantation of a Cilco Kratz modified J-loop lens, the patient, a 79-year-old white female, developed a severe granulomatous uveitis unresponsive to topical or systemic steroid therapy. All usual uveitis tests were negative, and no evidence of masquerade-syndrome-type uveitis was found. The possibility of lens-induced uveitis was considered. A B-scan ultrasound revealed high density echoes in the superotemporal portion of the capsular bag, and an operative procedure consisting of a sector iridectomy, removal of the implant, removal of white cortical material in the capsular bag as well as residual lens capsule, and an anterior vitrectomy was done. Pathologic examination of the specimens revealed lens material engulfed by large macrophages, foam cells, and plasma cells. The patient's uveitis rapidly subsided. She is now off all medication and has normal aphakic vision. The differential diagnosis, surgical management, and implications of this problem are discussed.

Aged↗
PubMed1983

Longitudinal study of serum antibody responses to bovine retinal S-antigen in endogenous granulomatous uveitis.

Twelve patients with granulomatous uveitis were followed up longitudinally for as long as 20 months after their initial visit, and multiple serum antibody titres to bovine retinal S-antigen were determined and compared with the clinical activity at the time of each sampling. In those patients who presented with highly active lesions which then resolved during the course of the study without recurrences (7 toxoplasmosis and 1 pars planitis) the antibody titres reached a peak approximately 2 months after the initial visit and declined thereafter. No correlation of serum anti-S titres with clinical activity or predictable pattern of titres could be found in those patients who had recurrences during the course of the study (3 granulomatous iridocyclitis and 1 ocular sarcoidosis).

Antibodies↗
PubMed1983

Immunologic and biochemical properties of several retinal proteins bound by antibodies in sera from animals with experimental autoimmune uveitis and uveitis patients.

Sera from guinea pigs and rabbits with and without experimental autoimmune uveitis (EAU) induced by immunization with retina, choroid, optic nerve, retinal rod outer segments (ROS) and purified bovine S-antigen were tested for the ability to immunoprecipitate 125I-labeled, detergent-solubilized bovine retinal proteins. The results demonstrate that three major protein antigens with m.w. of 50,000 (p50), 35,000 (p35) and 27,000 (p27) and several minor activities between 30,000 and 60,000 m.w. are recognized by antibodies from these animals. The p50 component was immunoprecipitated by sera from animals immunized with whole retina homogenate, the high speed supernatant of whole retina homogenate, ROS, and S-antigen, and has been identified as S-antigen in competition experiments. The p35 band appeared when sera were used that were raised against antigen preparations containing membrane-bound retinal protein, i.e., whole retina homogenate, ROS, and washed ROS, and thus appears to be an ROS membrane protein. The p27 band was found when sera raised against ROS, washed ROS, optic nerve and whole retina homogenate were used, suggesting it is a membrane-bound antigen common to ROS and optic nerve. Serum from animals immunized with homologous choroid did not immunoprecipitate a detectable product. S-antigen and p35 were also precipitated by some uveitis patient sera. Because S-antigen is also an ROS protein as is rhodopsin, a putative uveitogenic retinal antigen, ROS appear to be an unusually rich source of autoantigenic proteins. S-antigen was also shown to be synthesized in the retina, and the primary translation product was indistinguishable from purified S-antigen by SDS-PAGE, thus eliminating the possibility that it is derived from or is cross-reactive with the 67,000 m.w. rhodopsin kinase.

Animals↗
PubMed1982

Longitudinal study of serum antibody responses to retinal antigens in acute ocular toxoplasmosis.

We conducted a longitudinal study of five patients with anterior and posterior acute toxoplasmic uveitis to determine the relationships, if any, between the level of toxoplasmic activity, therapy, and serum antibody titers to retinal proteins. All patients showed increased serum antibody responses to S-, P-, or p59ag-antigen isolated from bovine retina. The titers to S-antigen tended to decrease with clinical improvement and stabilized at titers somewhat higher than normal; the anti-p59ag titers decreased in those patients treated with clindamycin and sulfadiazine and remained increased throughout the acute attack and remained increased even after the attack ended.

Adult↗
PubMed1982

Serum antibody responses to bovine retinal S-antigen and rod outer segments in proliferative diabetic retinopathy before and after argon laser photocoagulation.

Using the enzyme-linked immunosorbent assay, the serum antibody titers to bovine retinal S-antigen and rod outer segments in pre- and post-argon laser treated diabetic retinopathy patients were compared to each other and to the titers of age- and sex-matched normal controls. The increase in anti-S titer following the initial laser treatment gave a P less than 0.01 using the two-tailed paired Student's t-analysis as compared to the prelaser anti-S titer. Both pre- and post-laser anti-S titers were elevated over normal controls with P values of less than 0.02 and less than 0.001, respectively. Eight weeks after the initial laser treatment, anti-S titers began to decline approaching control levels 12 weeks later. No significant change was found between pre- and post-laser titers when rod outer segments were used as antigen although the pre- and post-laser titers were increased over normal controls with P values of less than 0.05 and less than 0.001, respectively. The release and possible alteration of retinal components following photocoagulation may account for the rise in anti-S titers, while the prephotocoagulation titers may be due to retinopathy-related photoreceptor cell alteration.

Adult↗
PubMed1981

Serum antibody levels of uveitis patients to bovine retinal antigens.

Serum samples from 91 uveitis patients and controls were tested by the enzyme-linked immunosorbent assay technique to determine their relative antibody titers to bovine retinal S antigen and to a detergent extract of saline-washed bovine retina, or P antigen. Only those patients whose uveitis fell into the categories of toxoplasmosis, iritis, herpes keratouveitis, pars planitis, sarcoidosis. Behçet's syndrome, and Vogt-Koyamagi-Harada syndrome are presented in this study. Significantly elevated titers (P less than 0.05) of antibody to S antigen were found in the diagnostic categories of iritis, toxoplasmosis, sarcoidosis, and Behçet's. Elevated titers to the detergent extract were found in iritis (granulomatous and hypopyon subcategories only), toxoplasmosis, sarcoidosis, and Vogt-Koyanagi-Harada syndrome. The anti-S titers of patients treated with systemic steroids were depressed below normal levels. A separate control group of patients with nonuveal ocular inflammations (conjunctivitis, episcleritis, etc.) had titers very similar to normal controls. The posttreatment titers to S antigen of patients receiving laser photocoagulation for diabetic retinopathy were significantly elevated over normal controls.

Antibodies↗
PubMed1971

Sclerocornea.

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Abnormalities, Multiple↗