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Biomedical subjects

I W SIZER

Publications and source records attributed to I W SIZER.

At least 19 recordsLinked to original sources
PubMed1965

HISTONE REGULATION OF LACTIC DEHYDROGENASE IN EMBRYONIC CHICK BRAIN TISSUE.

Histone, when added at low concentrations to cultures of embryonic chick brain tissue, causes an inductive response in lactic dehydrogenase activity, whereas at higher concentrations of histone the response is repressive. This control is shown to operate by altering protein synthesis. Thus, histones exercise a primary regulatory function in the chick. Unlike lactic dehydrogenase, acetylcholine esterase is stable in this system and is not affected by histones or inhibitors of protein synthesis.

Acetylcholinesterase↗
PubMed1957

Chemical aspects of enzyme inhibition.

The use of chemical reagents as enzyme inhibitors has yielded information concerning the mechanism of inhibition and the role in catalysis played by active groups on the protein apoenzyme, the coenzyme, or the metal component. Inhibition analysis has also furnished valuable clues concerning the architecture, chemical properties, and catalytic mechanism of the active site of the enzyme. In many cases, in vivo effects of inhibitors can be closely correlated with in vitro inhibition of purified enzyme systems. The effects of antimicrobial and anticancer agents, insecticides, and drugs can often be explained in terms of enzyme inhibition. The design and synthesis of new inhibitors offers great promise when applied to the control of undesirable organisms and to the prevention and cure of disease in the immediate future.

Catalysis↗