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Biomedical subjects

I W Whimster

Publications and source records attributed to I W Whimster.

17 recordsLinked to original sources

Carcinoma (epithelioma) cuniculatum: a clinico-pathological study of nineteen cases and review of the literature.

Nineteen patients with carcinoma cuniculatum are presented. Of these, 17 were male and two were female. The age range was from 26 to 73 years with a mean of approximately 54 years. Sixteen tumours were located on the foot, the other three were situated on the knee, wrist and finger respectively. The pathological features of carcinoma cuniculatum are described and the aetiology of the tumour is discussed.

Adult↗

The focal differentiation of pigment cells.

A study has been made of the normal development and of the regeneration after excision of the groups of large pigment cells which form the spotted skin pattern of the gecko Eublepharis macularius, together with the effects of neonatal graft transplantation on this pattern. The results all indicate strongly that such groups of specialized pigment cells are not clones but the product of an induction process. This is then compared with the neural reflex mechanism by which the skin pattern of Chamaeoleo dilepis is formed.

Animals↗

Spreading pigmented actinic keratoses.

The clinical and histological features of ten pigmented keratoses arising on the face are described. They were all greater than 1.5 cm in diameter and had been spreading centrifugally. They were variably pigmented and possessed either a smooth, verrucous or slightly scaly surface. Two lesions had progressed to become pigmented squamous cell carcinomas.

Aged↗

The pathology of lymphangioma circumscriptum.

A study of lymphangioma circumscriptum has been carried out over a number of years in an attempt to understand its nature and pathogenesis, with a view to improving treatment. It is postulated that the lesion consists essentially of a collection of large muscular-coated lymphatic cisterns, lying deep in the subcutaneous plane and communicating via dilated dermal lymphatics with the superficial vesicles. It seems that these cisterns do not communicate directly, if at all, with the general lymphatic system but represent a sequestrated part of it. They have been shown by cannulation to pulsate at a slow steady rate producing a rise and fall of pressure within them. It is believed that the vesicles are saccular dilatations of superficial lymphatics, secondary to raised pressure transmitted from the pulsating cisterns beneath. It is suggested that may be possible to treat these lesions more successfully and with better cosmetic results by excising the subcutaneous cisterns and leaving the overlying skin intact.

Adolescent↗