Biomedical subjects

I Wecker

Publications and source records attributed to I Wecker.

7 recordsLinked to original sources

PubMed1988

Gardnerella vaginalis is associated with other sexually transmittable microorganisms in the male urethra.

In a prospective study, urethral swabs were taken from 544 men presented to an STD clinic, 118 with and 426 without urethritis, and examined by microscope and/or culture for G. vaginalis, Chlamydia trachomatis, Neisseria gonorrhoeae, Ureaplasma urealyticum, Mycoplasma hominis, Candida species and Trichomonas vaginalis. G. vaginalis was isolated from 4.2% of the males with urethritis and from 6.3% of those without urethritis. Using loglinear analysis, the following associations were significant (p less than 0.05): three-way: G. vaginalis, U. urealyticum, C. trachomatis; two-way: G. vaginalis, U. urealyticum and G. vaginalis, M. hominis and U. urealyticum, M. hominis. It is concluded that G. vaginalis is associated with genital mycoplasmas not only in the female, but also in the male urogenital tract.

Adolescent↗

PubMed1987

Sexually transmittable organisms in the urethra of males with and without urethritis.

In 589 males, 169 with and 420 without urethritis, urethral swabs were taken and assessed semiquantitatively for the sexually transmittable infectious agents Neisseria gonorrhoeae, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, Trichomonas vaginalis and Candida species. The organisms were isolated in patients with and without urethritis as follows: N. gonorrhoeae with urethritis 19.5%, without 0.0%; C. trachomatis with urethritis 16.0%, without 2.9%; U. urealyticum (high cfu-counts) with urethritis 27.2%, without 11.7%; M. hominis (high cfu) with 4.7%, without 2.9%. Combined infections were more frequent in males with urethritis (20.8%) than in those without (5.4%). None of the investigated pathogenic microorganisms could be demonstrated in 37.9% of males with and in 71.2% of males without urethritis. Using loglinear analysis, a significant coincidence of infections with N. gonorrhoeae and U. urealyticum and of infections with U. urealyticum and M. hominis was found. It is concluded that an asymptomatic infection of the male urethra with sexually transmittable organisms is to be expected in partner's control examinations and in patients presenting for other STD like venereal warts or genital herpes. Therefore in these men, even if they are asymptomatic, a comprehensive microbiological examination is strongly recommended.

Adolescent↗

PubMed1979

[Immunity against poliomyelitis in the German Federal Republic (author's transl)].

The immunity of the populations of several countries of the GFR against poliovirus 1, 2 and 3 was investigated in 11 laboratories. Sera of 4707 persons aged 0 to 30 years were assessed for neutralising antibodies (serum dilution 1:4) against the 3 types of poliovirus. 34.5% of the 4707 investigated sera had no neutralising antibodies at least against one type of the poliovirus, 4.7% showed no antibodies against all 3 types of the virus. Especially children aged 0 to 4 years were protected incompletely against the 3 types of poliovirus. In comparison with similar investigations of 1969 and 1972 no decisive change of immunity of the population of the GFR against poliomyelitis has occurred.

Adolescent↗

PubMed1979

[Generalized herpes simplex].

This report is about a 58-year-old female patient with generalized herpes simplex virus exanthema. The virus was detected not only in the skin eruptions but also in rinsing liquid from the throat. Its typical feature revealed it to be herpes simplex virus Type I. On the basis of similar cases which have been described in literature, we point out that it is necessary to carry out virological and serological tests in cases of uncertain vesico-pustular or erythema exsudativum multiforme like exanthemas. These exanthemas must be separated from the postherpetic erythema exsudativum multiforme because of the identified virus.

Exanthema↗

PubMed1978

[Echovirus 30 epidemic (author's transl)].

Echovirus 30 was the cause of abacterial meningitis and pharyngitis in 22 cases in the Ludwigshafen on Rhine area in summer 1976 and in a further 26 cases in various regions of the German Federal Republic. In 11 children echotype-30-virus could be isolated from the CSF. In 47 children the diagnosis was established by a rise of neutralising antibodies. Positive virus isolation from the CSF was only possible during the first two days of the illness using rhabdomyosarcoma cell tissue cultures. These were particularly sensitive to the echovirus 30 subtype found.

Adolescent↗

PubMed1977

RD cells in the laboratory diagnosis of enteroviruses.

It is shown that, in addition to the already known replication of Coxsackie A viruses, 16 out of 18 different types of ECHO viruses tested as well as all three types of polioviruses can also be grown in RD cells with the development of a pronounced CPE. One of the exceptions, ECHO virus type 16, can be propagated in either HEL or HFDK cells and the other, ECHO virus type 22, in Vero cells. These four permanent or semi-permanent cell cultures thus prove very useful for the isolation of most of the diagnostically important enteroviruses as well as for their serological identification by neutralization in a micro-titer system described in this paper.

Cell Line↗

PubMed1977

The use of RD cells in the isolation of Echo type 30 virus from patients with aseptic meningitis.

Between early July and August 1976, 60 cases of aseptic meningitis and pharyngitis in children from various parts of West Germany were reported to this institute. Successful virus isolation from spinal fluid in 12 out of 36 cases was greatly facilitated by the use of RD cell tissue cultures, whereas isolation attempts in HEL, Vero, and HFDK cells were unsuccessful. In all cases, the isolated virus was identified as ECHO type 30. Neutralization studies with sera of 48 remaining cases also using RD cells clearly indicated that the epidemic outbreak was caused by ECHO type 30 virus.

Cells, Cultured↗