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Biomedical subjects

I Wodinsky

Publications and source records attributed to I Wodinsky.

At least 37 records · Page 2Linked to original sources

Transport and phosphorylation as factors in the antitumor action of cytosine arabinoside.

Survival of mice bearing different transplantable leukemias and treated with cytosine arabinoside was compared with uptake and subsequent phosphorylation of the drug in vitro. Capacity for nucleotide formation was correlated with response and is apparently an important determinant of drug sensitivity. Drug uptake, although apparently mediated, was similar in all cell lines.

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Uptake as a determinant of methotrexate response in mouse leukemias.

Methotrexate-promoted survival of mice bearing different transplantable leukemias was compared with uptake of the drug by leukemia cells in vitro. A high degree of correlation (r(2) = 0.88) showed that uptake may be a major determinant of the antitumor activity of methotrexate against transplantable mouse leukemias.

Animals↗