Biomedical subjects
Publications and source records attributed to I Z Akhmetov.
The dynamics of radioactive iodine accumulation in some organs and tissues of experimental and wild rodent has been studied. The data obtained indicate the seasonal changes in accumulation investigated. These changes correlate with the dynamics of thyroid gland functional state.
The reaction of wild rodent thyroid gland on emotional and painful stress appearing as a result of animal's catching has been studied. The thyroid activity has been shown to raise considerably during the primary stage of stress reaction. Later on the function of the gland normalizes in animals without trauma and in traumatized animals it becomes weaker. The complete normalization of the thyroid function in traumatized animals coincides with osteal regeneration according to time.
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The studies were carried out on rodents with different ecology, suffering from alimentary obesity. Their weight was 1.3-1.5 that of control animals. Prolonged (3 months) maintaining of the animals in conditions of obesity led to sharp decrease in inclusion of 131I into thyroid parenchyma, synthesis and excretion of SB 131I into blood. Microscopy study of thyroid gland revealed an inhibition of hormone synthesis, as indicated by flattened epithelium, dense colloid in follicles, and other hypofunctional features. Obesity decreases the quantity of food consumed by the animals and their reproductive abilities. Comparison of data obtained on rodents with different ecology revealed that maximal inhibition of thyroid function at obesity was observed in yellow gopher as compared to rat and gerbil.
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Studies have been made on the effect of high temperature and intensive insolation upon the uptake of iodide and hormone formation in the thyroid of rodents (Rhombomys opimus, Spermophilopsis leptodactylus, Citellus fulvus) with different adaptation to the environment. It was shown that high temperature in combination with solar radiation significantly decreases functional activity of the thyroid and affects some of the physiological indices of the organism. Animals with different ecological specialization differ in their reaction to factors of the hot climate.