Flagellate erythema after intraperitoneal bleomycin.
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Aged↗
Biomedical subjects
I Zaki
Publications and source records attributed to I Zaki.
Dermatomyositis associated with malignant melanoma--case report and review of the literature.
Dermatomyositis (DM) is a connective tissue disorder characterized by cutaneous and muscle involvement. It is a well recognized paraneoplastic syndrome and has been linked with malignancy in 15-34% of adult patients. The course of DM in such patients usually correlates closely with the activity of the underlying malignancy. We report a patient who developed DM 4 years after excision of a malignant melanoma (MM) from the back and 1 year before the diagnosis of metastatic disease. A literature review revealed that the association of dermatomyositis with MM is rare and consistent with a dismal prognosis.
Dermatomyositis↗
Primary anetoderma: phagocytosis of elastic fibres by macrophages.
We report a 22-year-old female with a 2-year history of increasingly numerous well-circumscribed, asymptomatic skin lesions. The clinical and histological features were consistent with anetoderma and investigations failed to reveal any associated underlying disorders. Electron microscopy of abnormal skin showed phagocytosis of elastic fibres by macrophages. Although the aetiology of primary anetoderma remains unknown, this finding suggests that phagocytic destruction of elastic fibres plays a major role in its pathogenesis.
Adult↗
Split skin grafting on severely damaged skin. A technique using absorbable tissue adhesive.
BACKGROUND: Patients with severely damaged skin are more likely to develop skin malignancies. However, suturing following excision of tumors is difficult due to their fragile skin. OBJECTIVE: To evaluate the effectiveness of a technique using butyl-2-cyanoacrylate tissue adhesive in split skin grafts in patients with severely damaged skin. METHOD: The technique was used in 19 patients with 24 skin tumors. Two patients also had multiple skin biopsies to assess the biodegradability of the adhesive. RESULTS: Split skin grafts were applied successfully in all patients. The adhesive was completely absorbed without a foreign body reaction within 6 months. CONCLUSION: We recommend the use of butyl-2-cyanoacrylate in split skin grafting patients with severely damaged skin.
Absorption↗
Bacitracin: a significant sensitizer in leg ulcer patients?
We report the results of patch testing 85 patients with either long-standing venous ulceration or eczema complicating their leg ulcers. As previously reported, lanolin and its derivatives and topical antibiotics were the most frequent sensitizers. However, unlike previously published data, we found bacitracin to be the most potent sensitizer of all topical antibiotics tested. There were no positive reactions in a control group of patients, although we were unable to repeat the patch tests in patients with a positive reaction to bacitracin. In the past 10 years, our department has used a proprietary mixture of polymyxin and bacitracin in treating infected leg ulcers and other dermatoses. It is therefore possible that chronic usage of topical bacitracin on leg ulcers carries a significant risk of contact sensitization.
Adult↗
Case report: mediastinal lymphadenopathy in eosinophilic pneumonia.
Chronic eosinophilic pneumonia is a relatively rare disorder characterized radiologically by non-segmental homogenous consolidation in the lung periphery [1]. We present a patient who had marked mediastinal lymphadenopathy as well as the more typical radiological features, which resolved rapidly with treatment.
Adult↗
Reticular erythematous mucinosis syndrome and a monoclonal IgG kappa paraprotein--is there an association?
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Aged↗
Carbamazepine-induced anticonvulsant hypersensitivity syndrome--pathogenic and diagnostic considerations.
Two epileptic patients developed an infectious mononucleosis-like illness which subsequently proved to be a carbamazepine-induced anticonvulsant hypersensitivity syndrome. Patch testing to carbamazepine 3 years later was positive in the one patient tested and negative in normal controls. The second patient died a few weeks after the illness, secondary to long-standing cardiac disease without having undergone patch testing. A skin biopsy was, however, consistent with an immune complex mediated drug reaction. Patch testing for systemically administered drugs is generally believed to be of little value in diagnosing drug allergies. However, we reinforce a previous suggestion that this investigation may be helpful in some cases of anticonvulsant hypersensitivity syndrome caused by carbamazepine. The pathogenic role of type 3 and 4 hypersensitivity is also discussed.
Adult↗
A comparison of the effect of viscosity on the precorneal residence of solutions in rabbit and man.
The precorneal drainage of radiolabelled solutions containing polyvinyl alcohol (PVA) or hydroxypropyl methylcellulose (HPMC) have been measured in rabbit and man by gamma scintigraphy. Concentration of the polymers was varied to produce solutions with a viscosity range between 10.2 and 102 mPas. Solution drainage was faster in man than in the rabbit with a more pronounced effect of viscosity. Significant retardation of drainage in man was noted at the higher polymer concentrations (0.9% HPMC or 5.85% PVA).
Adult↗
[Leucocyte alkaline phosphatase in normal and pathological pregnancy (author's transl)].
The activities of leucocyte alkaline phosphatase were determined in 511 patients with normal and pathological pregnancy. Mean values were compared and the enzyme followed up, and the conclusion was drawn that leucocyte alkaline phosphatase was no safe indicator of foetal condition. No direct relationship were found to exist between leucocyte alkaline phosphatase, total oestrogens, HSAP, HLAP, HPL, and oxytocinase.
Alkaline Phosphatase↗