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Ia I Lapuk

Publications and source records attributed to Ia I Lapuk.

6 recordsLinked to original sources
PubMedDate not supplied

[The effect of water-soluble sorbents on the exocrine function of the liver].

The effect of water-soluble sorbents on exocrine function of the liver was studied in chronic experiments on 2 dogs with a brought out bile duct. It is shown that choline and digitonin sorbents exhibit choleretic properties similar to those of cholestyramine. Choline sorbent causes a drop in the concentration of (2-4-fold) cholic acid in the bile unlike digitonin sorbent. No prolonging action was seen upon cholestyramine administration, while choline sorbent do demonstrate it. Cholesterol and bilirubin levels do not respond noticeably to the above sorbents.

Adsorption↗
PubMedDate not supplied

[Specific binding of cholesterol by enterosorbents].

Soluble polymers, modified by steroid glycosides digitonine or tomatonine (the "enterosorbents") bound cholesterol dissolved in alcohol. Rates of the binding depend on amount of the glycosides introduced into the sorbent. The digitonine or tomatonine enterosorbents decreased the cholesterol content in blood serum of hypercholesterolemic rats after per oral administration. At the same time, the enterosorbent containing digitonine decreased simultaneously both the content of liver tissue cholesterol and the content of atherogenic lipoproteins in rat blood serum.

Adsorption↗
PubMedDate not supplied

[Elimination of cholesterol by affinity chromatography].

Elimination of cholesterol from physiological fluids was carried out by means of affinity chromatography using digitonine as an affinity agent. For this purpose a method of covalent binding of digitonine with aminosylochrome was developed. The most suitable conditions for production of the stable sorbent specific for cholesterol are described. The ratio of concentrations of digitonine to sodium periodate was 1:2; oxidation was performed in a medium containing 50% aqueous dioxane within 1.5 hrs. The modified sorbent, used for affinity chromatography of cholesterol, possessed a specific capacity of 10 mg/g.

Arteriosclerosis↗
PubMedDate not supplied

[Enterosorbent with immobilized trimethylaminoethanol chloride. I. Hypolipidemic properties].

Hypolipidemic properties of the synthesized enterosorbent, water soluble polymer containing covalently immobilized trimethylamine ethanol chloride, were studied. Content of cholesterol in blood was decreased by 29% and accumulation of cholesterol in liver tissue--by 22% after oral administration of the enterosorbent at a dose of 250 mg/kg into rats with hypercholesterolemia. Cholestyramine exhibited the similar effect only at a dose of 2.5 g/kg. Except for the hypocholesterolemic effect, the enterosorbent altered also the lipoprotein spectrum in rat blood serum.

Animals↗