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Biomedical subjects

Ia O Ol'shanskiĭ

Publications and source records attributed to Ia O Ol'shanskiĭ.

14 recordsLinked to original sources
PubMed1982

[Features of inflammation of the mucosa of the large intestine in nonspecific ulcerative colitis and Crohn's disease].

Histological, morphometric, and immunohistochemical studies (with detection of the local production of IgA, IgM, IgG, IgE, and IgD, secretory component of IgA, and deposition of the third complement component, C3) were carried out on biopsies of the colon mucosa from 66 patients with recurrent and continuous forms of nonspecific ulcerative colitis and 16 patients with Crohn's disease. Inflammation in the colon mucosa in the diseases under study was found to be accompanied by marked activation of the local immune system, increased local production of IgA and IgM as well as IgG, particularly in those parts of the mucosa which had no glands. Local synthesis of IgE and IgD also increases indicating allergic reaction in the mucosa alongside with tissue eosinophilia. The basal membrane of the surface epithelium was found to have C3 depositions. A typical feature was the lack of correlation between infiltration of the layer proper of the mucosa and epithelium which is regarded to be a manifestation of deficiency of T-lymphocytes (subpopulation of suppressors or lymphocytes taking part in regulation of epithelium regeneration).

Biopsy↗
PubMedDate not supplied

[Nature of the interferon circulating in the blood of bronchial asthma patients].

For the elucidation of the nature of interferon circulating in the blood of patients with bronchial asthma in the period of exacerbation the sensitivity of the collected samples to pH 2.0 and 56 degrees C was determined and neutralization test with interferon anti-gamma-serum performed. All the 17 specimens under study were found to contain a mixed population of interferon presented mainly by the gamma-type (greater than or equal to 75%). The remaining amount of interferon (less than or equal to 25%) consisted of alpha- and/or beta-type. The prognostic value of the data obtained is discussed.

Antigens↗
PubMedDate not supplied

[Immune system indices in diabetes mellitus].

The immunological indices were studied in 24 patients with diabetes mellitus: 11 with insulin-dependent type (IDD) and 13 with insulin-independent type (IID). In the IDD patients sensitization to commercial insulin and bacterial allergens was more common in vitro than that in the IID patients. The per cent content of T-lymphocytes and an absolute number of phagocytic cells decreased in the peripheral blood of the IDD and IID patients. Both forms of diabetes mellitus were accompanied by disglobulinemia with an elevated serum immunoglobulin A level and a decreased immunoglobulin G content.

Adult↗