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Ian Fraser

Publications and source records attributed to Ian Fraser.

8 recordsLinked to original sources
PubMed2005

Liver iron concentration and fibrosis in a cohort of transfusion-dependent patients on long-term desferrioxamine therapy.

Secondary iron overload is associated with significant mortality and morbidity. Although new, less invasive techniques are becoming available, the most acceptable and readily accessible way to assess iron overload is to measure hepatic iron by liver biopsy. In this study, we report on serial liver biopsies (at least 2) in a cohort of transfusion-dependent patients (49) on long-term desferrioxamine treatment. There was no significant change in liver iron concentrations (LIC) even in the medication-compliant patients, although there was an upward trend (not statistically significant) in the poorly compliant patients. Fibrosis was present in both HCV RNA-positive and -negative patients, but was more common in positive patients and there was also a significant relationship between fibrosis and hepatic iron concentration. Liver iron levels appear to be maintained in patients who are compliant to desferrioxamine treatment, but overall there is little evidence of significant improvement in liver iron in these patients and in the group as a whole.

Adolescent↗
PubMed2005

Pelvic recurrence in stage I seminoma: a new phenomenon that questions modern protocols for radiotherapy and follow-up.

OBJECTIVE: To highlight the increased risk for pelvic relapse in patients with stage 1 seminoma treated with adjuvant radiotherapy limited to para-aortic template alone. PATIENTS AND METHODS: Over a four-year period, three patients presented with early pelvic recurrence after radical orchidectomy and adjuvant irradiation for stage 1 seminoma. In each case, radiotherapy had been limited to the para-aortic region with omission of the ipsilateral hemi pelvis. RESULTS: Pelvic recurrences occurred on the ipsilateral tumor side. Durable complete remission was achieved in each case; however, treatment was complex and there was associated morbidity. CONCLUSION: This significant incidence of pelvic recurrence questions the validity of modern radiotherapy protocol which excludes the ipsilateral pelvis from the radiation field.

Adult↗
PubMed2005

Surviving a viva.

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Anti-Anxiety Agents↗
PubMed2005

Lack of correlation between iron overload cardiac dysfunction and needle liver biopsy iron concentration.

In 58 patients with transfusion dependent anemia, we compared cardiac function, as assessed by gated pooled cardiac scan at rest and during exercise stress, with liver iron concentrations (LIC) as determined by adequate biopsy samples. There was no relationship between LIC and cardiac function and deaths occurred in patients with LIC levels below those that are usually associated with cardiac death. LIC should not be used as a surrogate to determine risk of cardiac complications but purely for management of the hepatic iron load. Other methods, particularly magnetic resonance imaging, should be used to assess cardiac iron overload.

Adolescent↗
PubMed2005

Australian women's experience with Implanon.

AIM: To describe Australian women's experiences and acceptability of etonogestrel releasing subdermal contraceptive implant (Implanon). METHODS: Six hundred and fifty-one women were recruited at the time of implant insertion and asked to complete a self administered questionnaire immediately after insertion and at 3, 6 and 12 months after insertion. RESULTS: Four hundred and seventy-five women aged 15-50 years responded at least once. Forty-one women had the device removed before 3 months, 48 between 3-6 months, and 75 between 6-12 months. Removal was mainly because of side effects, especially frequent or prolonged vaginal bleeding which was the reason for significantly more women to have their device removed (18% at 3, and 37% at 12 months) compared to women with no or infrequent bleeding. Most rated the implant as "good to excellent", including 56/164 of those who discontinued its use in the first 12 months. DISCUSSION: Implanon is acceptable contraception to women in all reproductive age groups. Change in bleeding patterns was the main cause for dissatisfaction. Providing women with detailed information before insertion of the implant is important.

Adolescent↗
PubMed2003

Human uterine vascular structures in normal and diseased states.

Menstrual bleeding disorders are one of the most common problems presenting to the gynaecologist. There is increasing evidence that alterations in human uterine vascular structures are associated with spontaneous and sex steroid-induced changes in menstrual bleeding patterns. This article will discuss the normal anatomy and physiology of uterine vascular growth, breakdown, and repair and will indicate where altered anatomy and function may contribute to menstrual disorder. In particular, impact of low-dose progestogens on the endometrial vasculature and endometrial vascular fragility will be discussed. Disturbances of myometrial vascular growth and remodeling, including fibroids, adenomyosis, implantation, and arterio-venous malformations will also be addressed.

Endometrium↗
PubMed2003

3-dimensional imaging of collagen using second harmonic generation.

Collagen is the most important structural protein of the animal body. Its unique triple-helix structure and extremely high level of crystallinity make it exceptionally efficient in generating the second harmonic of incident light, and we show here how this leads to a novel mode of microscopy of immediate practical significance in medicine and biology. In particular, it provides sensitive and high-resolution information on collagen distribution, discriminates between type I and type III collagen, and allows both a greater understanding of and a sensitive test for cirrhosis of the liver. Future research applications could include wound healing and hereditary collagen diseases such as osteogenesis imperfecta.

Animals↗