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Biomedical subjects

Ian Orme

Publications and source records attributed to Ian Orme.

3 recordsLinked to original sources
PubMed2005

NIH pre-clinical screening program: overview and current status.

The increase in the number of cases of Mycobacterium tuberculosis around the world has lead to a greater need for a more efficacious vaccine than the currently used M. bovis BCG. Despite the relative success of this attenuated vaccine there are multiple examples where alternative strategies are desperately needed. In 1996, the National Institutes of Health published a request calling for applications to test newly developed vaccines against tuberculosis. The current screening program at Colorado State University has tested a wide range of novel vaccine candidates.

Adjuvants, Immunologic↗
PubMed2004

Adaptive immunity to mycobacteria.

Advances are now being made in terms of understanding both the initiation of the adaptive or acquired response to tuberculosis infection and its interface with elements of the innate response, as well as much later events in terms of the chronic disease state where reactivation can potentially occur. Despite this, there are still several elements of the adaptive response that remain poorly understood.

Animals↗