Biomedical subjects

Ilhan Karacan

Publications and source records attributed to Ilhan Karacan.

7 recordsLinked to original sources

PubMed2005

Bone loss in males with ankylosing spondylitis: its relation to sex hormone levels.

OBJECTIVE: Osteoporosis is a common complication of ankylosing spondylitis (AS). The aim of the present study was to assess the association of sex hormone levels with bone loss in males with AS. DESIGN: A cross-sectional study. Patients The study group consisted of 58 male patients with primary AS. The mean age was 38.2 years (range 18-59 years). MEASUREMENTS: Bone mineral density (BMD) was measured in the left proximal femur. Serum FSH, LH, total testosterone (T), dehydroepiandrosterone sulfate (DHEAS), oestradiol (E2) and progesterone levels were measured. RESULTS: Bone loss was observed in 54.5% of cases at the femoral neck and in 52.3% of cases at the trochanter and total hip. Bone loss was found in 40 (69%) cases in at least one of these three regions. Serum DHEAS was low in 12 (30.8%) of the cases with bone loss, and one (5.9%) of those without (P = 0.043). The ratio of serum T/DHEAS was higher in those with bone loss (5.24 +/- 3.70) than in those without (3.58 +/- 3.16) (P = 0.026). CONCLUSIONS: The results showed that bone loss might be related to low serum DHEAS levels in males with AS.

Adolescent↗

PubMed2004

Facet angles in lumbar disc herniation: their relation to anthropometric features.

STUDY DESIGN: Cross-sectional study. OBJECTIVE: To investigate the alteration of facet joint angle and its relation to anthropometric features in lumbar disc herniation. SUMMARY OF BACKGROUND DATA: In the previous studies, the facet tropism and its relation to the level, type, side, and development of lumbar disc herniation were reported. This study was the first to correlate anthropometric feature, facet angle, and asymmetry in patients with lumbar disc herniation. METHODS.: Sixty-one patients with lumbar disc herniation were included in this study. The body height, vertex-to-spina iliaca posterior superior distance, spina iliaca posterior superior-to-floor distance, and net weight were measured and body mass index calculated. The facet angles were measured for each facet joint using computed tomography. The intraobserver error was found to be +/- 1.66 degrees. We defined facet tropism as the bilateral angle difference greater than 2 intraobserver errors. The asymmetry rate was a ratio of degree of angles of the more coronally oriented facet joint to the more sagittally oriented facet joint at the same intervertebral level. RESULTS: The facet asymmetry was observed at the herniation level in 70.5% of the patients. There was a correlation between the degree of the more sagittally oriented facet joint angle and facet asymmetry rate at the herniation level (R = -0.684, P = 0.0001 for L4-L5 lumbar disc herniation; R = -0.509, P = 0.008 for L5-S1 lumbar disc herniation). The body height correlated with the degree of the more sagittally oriented facet joint angle, the degree of more coronally oriented facet joint angle, and asymmetry rate, respectively (R = -0.571, P = 0.0001; R = -0.474, P = 0.002; R = 0.314, P = 0.045, respectively). There was no correlation between the degree of these angles and the vertex-to-spina iliaca posterior superior distance. The spina iliaca posterior superior-to-floor distance was correlated with the degree of the more sagittally oriented facet joint angle (R = -0.457, P = 0.0001) and more coronally oriented facet joint angle (R = -0.435, P = 0.004) but not with the asymmetry rate. The degree of facet angles was not correlated with body weight and body mass index. CONCLUSION: This study revealed that patients with lumbar disc herniation had the asymmetry and sagittalization of facet joints, and these alterations were more evident in the taller patients.

Adult↗

PubMed2004

Bone loss in the contralateral asymptomatic hand in patients with complex regional pain syndrome type 1.

Regional osteoporosis was seen radiographically in clinically affected areas in patients with complex regional pain syndrome type 1 (CRPS1). The aim of the this study was to investigate whether bone loss developed in the contralateral hand in patients with unilateral CRPS1 of the hand. Thirty-two patients with CRPS1 of the hand were included in this study. Bone mineral density was measured in the left proximal femur and both ultradistal radiuses, using dual-energy X-ray absorptiometry. The subjects were classified as grades 1 to 3 according to the T-score of both ultradistal radiuses (densitometric grades): grade 1, both radiuses were normal; grade 2, bone loss was determined only in the affected radius; and grade 3, there was bone loss in both radiuses. Twenty (62.5%) patients had bone loss in the affected hand; 11 patients (34.4%) had bone loss only on the affected side and 9 patients (28.1%) had bone loss on both sides. The mean duration of the period between the diagnosis of the injury and the measurement of bone density was 1.9 +/- 0.6 months in patients with grade 1, 3.1 +/- 1.0 months in patients with grade 2, and 5.5 +/- 2.2 months in patients with grade 3. The Spearman test showed a significant correlation between the period of injury and the densitometric grade ( R = 0.774; P = 0.0001). In conclusion, the current study of patients with CRPS1, showed that the bone loss in the asymptomatic contralateral hand developed at a later stage than that in the affected hand. This bone loss was less frequent and of a lower degree in the asymptomatic contralateral hand than in the affected hand. The bone loss in the asymptomatic contralateral hand could be explained by the loss of sympathetic tone in CRPS1 and contralateral sympathetic innervation.

Absorptiometry, Photon↗

PubMed2003

Bone status in multiple sclerosis: beyond corticosteroids.

The aim of this study was to determine the possible factors affecting bone mineral density (BMD) in multiple sclerosis (MS). In this cross-sectional study, 65 clinically definite MS patients and 72 comparable controls were prospectively evaluated. To assess bone mineral metabolism in MS, the BMD of the lumbar spine and hip (femoral neck, trochanter and total) was measured by dual-energy X-ray absorptiometry, and serum vitamin D and parathyroid hormone levels and biochemical markers of bone turnover were also evaluated. MS patients had significantly lower BMD values than the control group at all measurement sites. There was a significant correlation between the disease duration and BMD values at the trochanter in women with MS. A correlation between femoral BMD values and functional status in women was also detected. There was no relationship between bone biochemical markers and BMD, except a negative correlation between bone alkaline phosphatase and trochanter BMD. Both disability and disease duration have an influence on BMD of the MS patients, whereas no significant correlation between glucocorticoid use and BMD was observed.

Adult↗

PubMed2003

Quantitative ultrasound evaluation of the hand: side dominance or overuse?

Mechanical loading is considered a very important factor affecting bone mass. To investigate the effect of heavy hand use on bone status in the dominant and nondominant hands, 17 ironers and a control group were evaluated with a new quantitative ultrasound system measuring the speed of sound (SOS). Both the dominant and nondominant hands were measured in all subjects, at both the proximal III phalanx and distal one-third radius. The ironers had significantly (p = 0.001) higher SOS values at the proximal III phalanx of the dominant hand than at the nondominant hand, whereas no difference was found between the hands in this group when measured at the distal one-third radius. There was no significant difference in SOS values as related to hand dominance in the control group. In conclusion, the SOS differences of the hands seems to be related to overuse rather than to side dominance.

Adolescent↗

PubMedDate not supplied

Evaluation of bone with quantitative ultrasound in healthy Turkish children.

In this study bone status was assessed using a quantitative ultrasound (QUS) technique at the calcaneus in 141 healthy, prepubertal, Turkish schoolchildren (80 girls, 61 boys) aged 6-12 years. Broadband ultrasound attenuation (BUA, DB/MHz) was measured with a prototype pediatric contact bone analyzer (CUBA, McCue Ultrasonics Ltd). The relation of age, body weight and height to BUA was assessed. BUA increased linearly with age in boys and girls (R=0.448, p=0.0001 and R=0.382, p=0.002, respectively). BUA values in boys tended to be higher than in girls, reaching significance only at the age of seven years with a 95% confidence interval. In conclusion, the measurement of BUA in the calcaneus with QUS has important clinical implications in assessing bone mass in children. Further studies in not only healthy children but also in those with metabolic bone diseases would be helpful in order to evaluate its sensitivity and reproducibility.

Anthropometry↗

PubMedDate not supplied

Computed tomographic evaluation of lumbar spinal structures during traction.

In the previous studies, it is reported that traction diminishes the compressive load on intervertebral discs, reduces herniation, stretches lumbar spinal muscle and ligaments, decreases muscle spasm, and widens intervertebral foramina. The aim of this study was to evaluate the effects of horizontal motorized static traction on spinal anatomic structures (herniated area, spinal canal area, intervertebral disc heights, neural foraminal diameter, and m.psoas diameter) by quantitative measures in patients with lumbar disc herniation (LDH). At the same time the effect of traction in different localizations (median and posterolateral herniation) and at different levels (L4-L5 and L5-S1) was assessed. Thirty two patients with acute LDH participated in the study. A special traction system was used to apply horizontally-motorized static lumbar traction. Before and during traction a CT- scan was made to observe the changes in the area of spinal canal and herniated disc material, in the width of neural foramina, intervertebral disc heights, and in the thickness of psoas muscle. During traction, the area of protruded disc area, and the thickness of psoas muscle decreased 24.5% (p = 0.0001), and 5.7% (p = 0.0001), respectively. The area of the spinal canal and the width of the neural foramen increased 21.6% (p = 0.0001) and 26.7% (p = 0.0001), respectively. The anterior intervertebral disc height remained unchanged with traction however the posterior intervertebral disc height was significantly expanded. This study is the first to evaluated in detail and quantitatively the effect of motorized horizontal lumbar spinal traction on spinal structures and herniated area. According to detailed measures it was concluded that during traction of individuals with acute LDH there was a reduction of the size of the herniation, increased space within the spinal canal, widening of the neural foramina, and decreased thickness of the psoas muscle.

Adolescent↗