PubMed Health⌕ Search

Biomedical subjects

Ingolf Sack

Publications and source records attributed to Ingolf Sack.

2 recordsLinked to original sources

Electromagnetic actuator for generating variably oriented shear waves in MR elastography.

Magnetic resonance elastography (MRE) is a recently developed technique for determining the mechanical properties of biological tissue. In dynamic MRE, electromagnetic units (actuators) are widely used to generate shear waves in tissue. These actuators exploit the interaction between the static magnetic field B(0) and an annular coil supplied with alternating currents. Therefore, coil movements are restricted to selected orientations to B(0). Conventional actuators transfer this movement collinearly to B(0) into the tissue. In this study, an electromagnetic actuator was introduced that overcomes this limitation. It is demonstrated that different directions of mechanical excitation can be generated and monitored by MRE. Different spatial components of the propagation of the shear waves were determined using agarose phantoms. The technique allows maximum contrast for MRE images of objects with anisotropic strain components such as muscle tissue.

Anisotropy↗

Analysis of wave patterns in MR elastography of skeletal muscle using coupled harmonic oscillator simulations.

The ability to study muscle elasticity in vivo would be of great clinical interest. Magnetic resonance elastography (MRE) has the potential to quantify noninvasively the distribution of the shear modulus in muscle tissue. Elasticity information may be derived by extracting frequencies from the wave patterns of phase-contrast MRE images. In a new approach, MRE wave patterns were reconstructed using 3D coupled harmonic oscillator calculations (CHO). To analyze in vivo MRE measurements of the biceps brachii of healthy volunteers, different anisotropic fibrous structures for the couplings between the muscle elements have to be assumed. V-shaped wave patterns as observed when excitation was applied on the tendon were reproduced by a model, where in a central band of stiff fascicles wave propagation was about twice as fast as that in surrounding tissue. Planar waves were observed for excitation near the muscle surface. They could be reconstructed by assuming a simultaneous wave excitation of all muscle fibers, where fibers along the main muscle axis were coupled more strongly than those perpendicular to the axis. The results show that CHO calculations provide a fast and reliable method for incorporating anatomical information of the investigated tissue in the reconstruction of complex wave patterns.

Acoustic Stimulation↗