Biomedical subjects

Insaf Hadj Ali

Publications and source records attributed to Insaf Hadj Ali.

4 recordsLinked to original sources

PubMed2006

[Clinical features and treatment in Cushing's disease. 18 cases].

We report a retrospective study about 18 Cushing's diseases in the department of endocrinology at Charles Nicolle hospital in 24 years. The mean age was 33.7 years with a male-female ratio of 4/14. Diagnosis was established on adrenocorticotropin hormone analysis and pituitary imaging. Transsphenoidal adenomectomy was released in 8 cases of Cushing's disease, it was successful in 5 patients (62.5%). Bilateral adrenalectomy was performed in three cases.

Adenoma↗

PubMed2004

[Treatment of Graves' disease: 300 cases].

OBJECTIVE: To try to select the best treatment among synthetic anti-thyroid agents, surgery and radioiodine in the case of Graves' disease. METHOD: We present a retrospective study of therapeutic and progressive aspects of 300 cases of Graves' disease. RESULTS: At the time of the diagnosis, the patients' mean age was of 38.17 years. Female sex predominated (70.7%). Medical treatment was prescribed in 25.7% of cases. Agranulocytosis occurred in one patient who died from septic shock. Surgery was performed in 29.3% of patients and 41% were treated with radioactive iodine. After a mean follow-up of 53.7 months, a progression towards euthyroidism was noted in 60, 22.7 and 21.7% of patients treated respectively with antithyroid drugs, surgery and radioiodine. Hypothyroidism was noted in around 40% of cases, 57.8% of which were treated surgically. Recurrent hyperthyroidism is more frequent with antithyroid drugs. CONCLUSION: Medical treatment increases the risk of relapse. It is therefore preferable to apply radical treatments in order to obtain permanent remission from hyperthyroidism.

Adult↗

PubMed2003

[Slipped capital femoral epiphysis associated with hyperparathyroidism. A case report].

Slippage of the upper femoral epiphysis can occur in association with multiple endocrine imbalances. A case of slipped femoral epiphysis with primary hyperparathyroidism is reported. The patient was an adolescent, 16 Years of age, who presented bilateral slipped epiphysis. Investigation showed that he had hypercalcemia (3.1 mmol/l) related to primary hyperparathyroidism. A parathyroid adenoma was removed. Outcome was favorable and the slipped femoral epiphyses did not require a specific treatment.

Adenoma↗

PubMed2002

[Suprasellar germinoma: two case reports].

Suprasellar germinomas are frequent in childhood and adolescence, particularly in male sex. The clinical and neuroendocrine abnormalities depend of tumor localization: Increased intracranial pressure, visual disturbances, hypopituitarism, Parinaud syndrome. We report two cases of suprasellar germinoma in young male patients (16 and 18 years old). The first patient hrad corticotorpin insufficiency and clinical signs of hypothyroïdism and hypogonadism. The second had central hypocorticism, hypothyroïdism and hypogonadism associated with central diabetes insipidus and hyperprolactinemia. The diagnosis of germinoma was confirmed after surgery by anatomopathologic examination in the first case and by stereotaxic biopsy in the second case. Treatment by radiotherapy improves prognosis of this disease.

Adolescent↗