Biomedical subjects

Ioannis Delakis

Publications and source records attributed to Ioannis Delakis.

3 recordsLinked to original sources

PubMed2005

MRI receiver frequency response as a contributor to Nyquist ghosting in echo planar imaging.

PURPOSE: To study the frequency response characteristic of the MRI signal receiver system as a contributing factor to the formation of Nyquist ghosting in echo-planar imaging (EPI). MATERIALS AND METHODS: Experimental work was undertaken on a 1.5 T system. A cylindrical test object filled with water was imaged axially with EPI in the center of the quadrature, transmit-receive head coil. In the first set of experiments, the water conductivity was increased progressively with the addition of salt between EPI acquisitions. In the second set of experiments, the conductivity of the water in the test object was kept constant and EPI images were acquired at several different bandwidths. A computer simulation was also implemented to demonstrate the impact of changes in the frequency response characteristic of the signal receiver system on EPI Nyquist ghosting. RESULTS: Experimental and simulation results showed that Nyquist ghosting increased with the variation of the frequency response characteristic within the effective frequency range determined by the image bandwidth. One can increase the variation in the frequency response characteristic by increasing its steepness over the image's bandwidth window when coil loading is decreased, or by increasing the effective frequency range when image bandwidth is increased. CONCLUSIONS: The results of this research may help reduce Nyquist ghosting in EPI studies when the imaging coil is not sufficiently loaded, such as in pediatric and phantom studies.

Algorithms↗

PubMed2004

Developing a quality control protocol for diffusion imaging on a clinical MRI system.

This work describes the development of a quality control protocol, which can be implemented to assess the accuracy, precision and reproducibility of the apparent diffusion coefficient (ADC) measurement on a clinical magnetic resonance imaging (MRI) system. The precision and accuracy of the ADC measurement are analysed with regard to MRI system noise, signal reproducibility and differences between nominal and effective b values. Two aqueous test-solutions of CuSO4 and sucrose are prepared for the quality control protocol. ADC measurement with the CuSO4 solution is more sensitive to differences between nominal and effective b values, on account of the solution's high ADC. ADC measurement with the sucrose solution is more sensitive to signal reproducibility due to the solution's low baseline signal intensity. The ADC of the test-solutions is measured on an MRI system at our centre with a sequence used for clinical studies using diffusion imaging. Two parameters, Q and R, are defined for the analysis of the quality control ADC values. The Q parameter is the ratio of the standard deviation of the quality control mean ADC values over time to the optimal standard deviation, as derived from the effect of thermal noise on the ADC measurement uncertainty. Analysis with the Q parameter indicates that signal reproducibility errors contribute to ADC variations on our MRI system when imaging with high b values (b > 500 mm s(-2)), whereas differences between nominal and effective b values have a greater impact on the ADC measurement when imaging with low b values (b < 500 mm s(-2)). The R parameter is defined as the ratio of the directional variation of the ADC quality control values to the uncertainty of the ADC measurement. Analysis with the R parameter shows that the effect of directional variation of the ADC measurement on our MRI system is more pronounced when imaging with low b values. The quality control protocol identified a systematic error, which introduced a small system-induced anisotropy in the ADC measurement. This error is currently taken into account in the analysis of clinical studies employing the diffusion imaging sequence used in this quality control protocol.

Anisotropy↗

PubMed2002

[Safety aspects in interventional MRI].

Because of its high soft-tissue contrast, Magnetic Resonance Imaging (MRI) is used increasingly for guidance and control of minimal invasive and neurological surgical procedures. Besides common precautions during an MRI investigation, special attention has to be paid to the consequences of MR compatibility, accuracy of localisation of interventional tools and geometrical distortions. As a new application of interventional MR intravascular procedures are developing that involve the introduction of guidewires, catheters and miniaturized coils with their leads into the blood vessels. Resonant currents and high electric fields can develop at the conductor ends, possibly causing burning lesions.

Equipment Design↗