Biomedical subjects

Ioannis Yiotakis

Publications and source records attributed to Ioannis Yiotakis.

5 recordsLinked to original sources

PubMed2006

Inverted papilloma of the sphenoid sinus: presentation of three cases.

INTRODUCTION: Inverted papilloma deriving originally from the sphenoid sinus is extremely rare. Three such cases are presented aiming to show the particularities and diagnostic clues of this clinical entity. CASE REPORTS: All three patients were male, and presented mainly with nasal symptoms. In all three cases imaging shows the sphenoid sinus was completely occupied by the tumor. Additionally the ethmoids and nasal cavities have been invaded in contiguity to the site of the initial appearance of the tumor. In particular one of the cases was of even more interest as a malignant transformation of the inverted papilloma of the sphenoid sinus was histologically observed. Endoscopic sinus surgery was the therapeutic approach chosen for all three cases, with very good results. Follow up 30 months after the operation has not revealed any signs of recurrence of the disease. CONCLUSION: Inverted papilloma of the sphenoid sinuses--and even more malignant transformation--although quite rare, may present occasionally. The ENT surgeon should be aware of this condition. Preoperative imaging with CT scan and MRI and the experience of the surgeon will dictate the appropriate surgical approach.

Adult↗

PubMed2003

Oral candidiasis in head and neck cancer patients receiving radiotherapy with amifostine cytoprotection.

This controlled study assessed the incidence of oral candidiasis, a xerostomia-related complication, in head and neck cancer patients receiving radiotherapy, with amifostine cytoprotection. Thirty-eight patients received 500 mg amifostine i.v., prior to each radiotherapy fraction, while 16 patients received radiotherapy alone. Oral candidiasis was diagnosed according to the criteria described before. Subjective xerostomia scales were completed by all patients. Mucositis was evaluated using the RTOG criteria. Oral candidiasis was diagnosed in 11/38 amifostine patients and in 9/16 controls (P = 0.07). Severe xerostomia was reported by 4/38 amifostine patients and by 7/16 controls. Oral candidiasis was reduced with amifostine cytoprotection. Oral candidiasis is suggested as an objective, early, though indirect, endpoint for amifostine's radioprotective effect on salivary glands.

Amifostine↗

PubMedDate not supplied

Cochlear dysfunction in patients with mitochondrial myopathy.

The present study investigates cochlear function in a group of 11 patients suffering from mitochondrial myopathy with normal or near normal audiometric pure tone thresholds, in most of whom diagnosis was histologically confirmed. A complete ENT, neurologic and audiological work-up, including transiently evoked otoacoustic emissions, was performed in all patients in order to estimate cochlear function. Compared to control subjects, most patients had absent otoacoustic emissions (OAE) in spite of normal hearing, indicating cochlear dysfunction. These findings suggest that subclinical involvement of the cochlea is quite common in patients with mitochondrial myopathy. Damage of the cochlea can be explained on the grounds of its increased metabolic rate, resulting in failure of the stria vascularis and the outer hair cells. Otoacoustic emissions might provide a useful tool in the clinical work-up and follow-up of these patients.

Adult↗

PubMedDate not supplied

Association between squamous cell carcinoma of the head and neck and serum folate and homocysteine.

UNLABELLED: The aim of this study was to evaluate the serum levels of folate and homocysteine in patients with squamous cell carcinoma of the head and neck (SCCHN) and to correlate them with the clinical stage. An attempt was made to associate the results with the effects of smoking. MATERIALS AND METHODS: Serum levels of folate and homocysteine were measured in 150 patients with histologically-proven SCCHN before any treatment and in 150 healthy volunteers (77 smokers and 73 nonsmokers). RESULTS: The study indicated a positive correlation between hyperhomocysteinemia and hypofolatemia and the presence of SCCHN. Folate deficiency and high levels of homocysteine were noted in a large number of healthy smokers. CONCLUSION: If metabolic disorders of the methionine cycle are confirmed as risk factors for SCCHN, folate as a dietary supplement might play a role in chemoprevention and the posttreatment care of SCCHN patients.

Aged↗

PubMedDate not supplied

Clinical effectiveness of tumor markers in squamous cell carcinoma of the larynx.

BACKGROUND: The aim of this study was to examine and compare the value of the serum tumor markers CYFRA 21-1, TPA-M, SCCA and CEA in squamous cell carcinoma (SCC) of the larynx. Moreover, their possible clinical applications were studied. MATERIALS AND METHODS: The serum levels of CYFRA 21-1, TPA-M, SCCA and CEA were measured in 79 patients with histologically-proven squamous cell carcinoma (SCC) of the larynx before and after treatment and in 77 healthy volunteers. The association of the results with the clinicopathological characteristics was investigated. RESULTS: The study showed that none of the markers revealed a significant sensitivity; TPA-M indicated a positive correlation with the grade of differentiation. CEA indicated a positive correlation only with distant metastasis. CONCLUSION: Among the four markers, only TPA-M may play a role in monitoring the success of therapy and follow-up in patients with SCC of the larynx.

Adult↗