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Biomedical subjects

Isaak Schipper

Publications and source records attributed to Isaak Schipper.

7 recordsLinked to original sources
PubMed2006

Diagnosis and management of bilateral posterior lenticonus in 7 members of the same family.

PURPOSE: To report on the occurrence of monosymptomatic bilateral posterior lenticonus in 7 members of the same family and discuss the diagnoses and methods of management. SETTING: Eye Clinic, Cantonal Hospital, Lucerne, Switzerland. METHODS: Two sisters were found to suffer from bilateral posterior lenticonus. The 3 sons of the elder sister and the 2 daughters of the younger sister all presented with bilateral posterior lenticonus. A cataract operation or a clear lens extraction with intraocular lens implantation was performed in 4 of the 7 patients. RESULTS: The disorder was found to be inherited and to follow a pattern of autosomal dominance. Visual acuity improved to 20/20 in all operated eyes. CONCLUSION: This may be the largest group in 1 family presenting with bilateral posterior lenticonus described to date. Treatment of posterior lenticonus, if necessary, can be successfully managed as an ordinary cataract.

Adolescent↗
PubMed2006

A novel complex mutation event in the peripherin/RDS gene in a family with retinal pattern dystrophy.

PURPOSE: To report a complex mutation in the peripherin/RDS gene found in a family in whom retinal pattern dystrophy is segregating as an autosomal dominant trait. METHODS: Clinical data were collected from family members of a large Swiss family affected by autosomal dominant retinal pattern dystrophy. Single strand conformation polymorphism (SSCP) analysis of the candidate gene peripherin/RDS and subsequent sequencing of the first exon were performed. RESULTS: Pattern dystrophy of the retina was suspected in 18 family members aged 30 years or older. Assuming a homogeneous phenotype, the candidate locus peripherin/RDS was investigated. SSCP analysis of the first exon of the peripherin/RDS gene showed an aberrant pattern in 18 affected individuals. Direct sequencing of polymerase chain reaction products detected a complex mutation, del265-268GCCA ins AGGGCC, leading to a stop codon at amino acid position 99. CONCLUSION: To our knowledge, we report the first complex mutation in the peripherin/RDS gene as the cause of a mild macular phenotype, supporting the importance of molecular diagnosis in genetic counseling.

Adult↗
PubMed2004

Glare sensitivity and optical side effects 1 year after photorefractive keratectomy and laser in situ keratomileusis.

PURPOSE: To compare the outcome of low-contrast visual acuity and glare sensitivity after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). SETTING: Department of Ophthalmology, Cantonal Hospital of Lucerne, Lucerne, Switzerland. METHODS: In this prospective study, patients selected PRK or LASIK after the advantages and disadvantages of both had been described. Snellen visual acuity and disability glare were measured with the Berkeley glare test preoperatively and 1 year postoperatively. At the 1-year follow-up, haze was graded and patients had to assess their quality of vision subjectively. RESULTS: One-year follow-up of 58 patients in the PRK group and 64 patients in the LASIK group was achieved. In both groups, the mean uncorrected visual acuity was 20/32 (P =.63) and the mean best corrected visual acuity, 20/20 with no statistically significant difference (P =.20). There were no preoperative or postoperative differences between the 2 groups in low-contrast visual acuity under 4 glare conditions. At 1 year, LASIK eyes had significantly lower postoperative haze scores than PRK eyes (P =.0013). The number of eyes with visually moderate and disturbing halos or disturbances in night vision did not differ considerably between the groups (P =.88). CONCLUSIONS: Efficacy outcomes were generally similar in the PRK and LASIK groups. Both achieved good objective and subjective results after treatment with a second-generation excimer laser.

Adult↗
PubMed2002

[Pars plana vitrectomy for pseudophakic retinal detachment].

BACKGROUND: Pars plana vitrectomy, usually without additional buckling procedures, is the first choice for repair of pseudophakic retinal detachment at the Lucerne Eye Hospital. PATIENTS AND METHODS: In a retrospective study we analyzed a consecutive series of 129 eyes (122 patients) treated for pseudophakic retinal detachment. All underwent a primary pars plana vitrectomy. 97 % had retrobulbar anaesthesia. SF6 was used in 93 %, Si-oil in 7 %. An additional encircling band was placed in 5 %. Mean age was 65 years (24 - 92, +/- 13). Minimal follow-up was 8 months (8 - 66, median 25). RESULTS: Mean duration of surgery was 90 minutes (50 - 140, +/- 15). Severe PVR grade C was present in 17 %. Breaks in the inferior part of the retina were found in 52 % - the localisation had no influence on the anatomical or functional outcome. A difference between preoperative and intraoperative findings was noted in 46 % (missed breaks or lattice degenerations etc.). For general medical reasons, Si-oil was not removed in 4 eyes. Complete reattachment after the first operation was achieved in overall 91 % (oil-left eyes were considered as failure); in 95 %, if the oil-left eyes were excluded from the study; in 93 %, if the eyes with encircling band were not counted; in 95 % without encircling-band and oil-left eyes; in 93 % without PVR-C cases; 95 % without encircling-band/oil-left/PVR-C eyes. Median final visual acuity was 1.0, if the macula was not detached preoperatively and 0.8, if the macula was detached. Intraocular pressure problems (> 30 mm Hg < 12 h and/or > 25 mm Hg > 36 h) were noted in 28 %. Prophylactic or therapeutic antiglaucomatous medication was applied in 58 %. 14 % showed a transient fibrin reaction in the anterior segment. Refraction and ocular motility were not influenced by the surgery. CONCLUSION: Primary vitrectomy for pseudophakic retinal detachment is safe and effective. Transient elevation of the intraocular pressure is a frequent postoperative complication.

Adult↗
PubMedDate not supplied

Combined pars plana vitrectomy and phacoemulsification with intraocular lens implantation in severe proliferative diabetic retinopathy.

BACKGROUND AND OBJECTIVE: To evaluate the results of combined vitrectomies and intraocular lens implantations in cases of proliferative diabetic retinopathy. PATIENTS AND METHODS: Data from procedures on 117 eyes (91 patients) undergoing combined pars plana vitrectomy, phacoemulsification, and intraocular lens implantation for the complications of proliferative diabetic retinopathy were analyzed retrospectively. Follow-up ranged from 8 to 64 months (median = 25 months). RESULTS: Retinal tears were the most frequent intraoperative problems (19%). Limited postoperative fibrin formation occurred in 22% of eyes. Within 6 months, 7% developed glaucoma and 2% showed new anterior segment rubeosis. Overall, 10% underwent secondary surgical procedures as follows: lavage for hemorrhage (n = 3), silicone oil exchange after 7 days for focal rebleeding (n = 1), silicone oil surgery for retinal detachment after gas resorption (n = 1), and lavage for late vitreous hemorrhage (7 to 13 months) (n = 4). Half of the secondary procedures were necessitated within 3 months of the original surgery. CONCLUSIONS: Combined surgery in proliferative diabetic retinopathy is safe and effective. It should be considered when lens opacities are either present or likely to develop soon.

Adult↗