[Guidelines for occupational asthma].
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Anti-Asthmatic Agents↗
Biomedical subjects
Isabel Isidro Montes
Publications and source records attributed to Isabel Isidro Montes.
Respiratory disease in aggregate quarry workers related to risk factors and Pi phenotype.
OBJECTIVE: To evaluate the respiratory health and its relationship with exposure to silica, smoking, alpha 1-antitrypsin, and Pi phenotype in aggregate quarries workers. METHODS: In a prevalence study, 378 subjects were studied, x-ray opacities and pulmonary function was analyzed in relation to cumulative dust exposure, smoking, alpha1- antitrypsin, and Pi phenotype. RESULTS: The adjusted odds ratio (OR) of round opacities (> or =0/1) was significantly related to smoking (P <0.001). The predicted forced expiratory volume in 1 second (FEV1) percentage had a negative relationship with the product dust. pack-years (P = 0.005). The OR of FEV1 <90% was 3.03 for smokers exposed to dust versus nonexposed nonsmokers (P = 0.049). The criteria for dust-tobacco interaction are satisfied. A subgroup with the highest level of alpha1-antitrypsin presented more opacities and worse pulmonary function. CONCLUSIONS: Radiologic alterations are found in relation to tobacco. The FEV1 has a negative relation with the product dust-tobacco. No alterations related to Pi phenotype are found. A subgroup with the highest alpha1-antitrypsin levels had more radiologic alterations and worse function.
Adult↗
Respiratory disease in a cohort of 2,579 coal miners followed up over a 20-year period.
INTRODUCTION: Working in coal mines is a risk factor for pneumoconiosis and COPD. There still exist, however, doubts and debates about the risk involved in such work for tuberculosis and lung cancer. The aim of this study was to clarify some of these uncertainties through the study of a cohort group. METHODS: The cohort comprises 2,579 miners. An initial medical examination was carried out when they began to work in the mine, and three further examinations were performed over the 20 years of the study. The follow-up failure rate was 23.7%. RESULTS: Ninety-nine workers (3.8%) developed round opacities (category 1) that were significantly related to the kind of work in a crude analysis (p = 0.045), with a greater frequency (7.3%) among rock workers, who have greater exposure to silica, and were almost significantly related to tobacco use (p = 0.092). These round opacities also show a significant relation to smoking, being more frequent (4.9%) among smokers, both in the crude analysis (p = 0.028) and in the multivariable analysis (p = 0.001) controlling for rock work. In 240 workers (12.7%), accelerated FEV(1) decreases were observed with significant relations to tobacco use (p = 0.001) and rock work (p = 0.044). Pulmonary tuberculosis was diagnosed in four cases, with an incidence of eight in 10(5) person-years. This rate falls within the limits expected for the region. No case of lung cancer was observed. CONCLUSION: In summary, our results showed the following: round opacities (category 1) were related to smoking and, probably, to rock work; accelerated FEV(1) decreases were related to rock work and tobacco consumption. There was no identified increase in tuberculosis or lung cancer in this cohort.
Coal Mining↗