Biomedical subjects

Ismail Jatoi

Publications and source records attributed to Ismail Jatoi.

21 records · Page 2Linked to original sources

PubMed2003

Internal mammary sentinel nodes in primary breast cancer.

For over a century, there has been considerable interest in the management of regional lymph node metastasis in patients with primary breast cancer. Since the advent of sentinel lymph node biopsies, there has been renewed interest in the management of patients with metastasis to the internal mammary nodes. The appropriate management of these patients has not yet been established. Some investigators propose that biopsy of the internal mammary sentinel node may provide additional prognostic information which might be used to guide the administration of systemic adjuvant therapy. Additionally, it has been suggested that patients with metastasis to the internal mammary sentinel node may benefit from radiotherapy to the internal mammary nodal chain. Clinical trials are needed to resolve these issues. Internal mammary sentinel node biopsy in patients with primary breast cancer should be considered investigational, and conducted only in the context of clinical trials.

Breast Neoplasms↗

PubMedDate not supplied

Current status of sentinel lymph node biopsy in early breast cancer.

In patients with primary breast cancer, the sentinel lymph node biopsy (SLNB) is a minimally invasive method of assessing nodal status, with the aim of reducing the morbidity of axillary lymph node dissection (ALND). The SLNB technique is relatively new, and there are several ongoing clinical trials to assess its long-term effects on survival, local recurrence, and morbidity. Yet, surgeons throughout the United States have already adopted it into their practices, and it is now widely used in the management of patients with primary breast cancer. In this article, we discuss some of the pertinent issues pertaining to the application of SLNB in the management of breast cancer.

Axilla↗

PubMedDate not supplied

MRI in breast cancer management: potential for benefit and harm.

Recently, there has been considerable interest in the application of magnetic resonance imaging (MRI) in the management of breast cancer. In women with a genetic predisposition for breast cancer, MRI screening is more sensitive than mammography screening. However, it is not known if the greater sensitivity of MRI screening has any impact on breast cancer mortality. Some investigators also have suggested that in women with primary breast cancer, MRI might be useful in determining suitability for breast-conserving surgery. However, the application of MRI in this manner may increase mastectomy rates without necessarily improving outcomes. Clearly, additional studies are needed to determine the optimal role of MRI in the management of breast cancer. In the meantime, patients should be informed of its potential for benefit and harm.

Breast Neoplasms↗