Biomedical subjects

Ismana Surković

Publications and source records attributed to Ismana Surković.

6 recordsLinked to original sources

PubMed2006

[Vaccine for prevention of type 1 diabetes mellitus].

Diabetes mellitus type 1, known as insulin dependent diabetes mellitus (IDDM), results from a chronic autoimmune destruction of the insulin secreting pancreatic beta cells. This autoimmune process is marked by circulating auto antibodies to beta cell antigens. GAD 65 (Glutamic Acid Decarboxylase) auto antibodies are present in 70-80% of newly diagnosed patients with type 1 diabetes, and it can be detected many years before clinical onset of the disease. New knowledge in the imunopathogenesis have given expectation that imunotherapy will become routine manner for cure of diabetes mellitus type 1.

Autoantibodies↗

PubMed2005

[Contemporary methods of prevention and treatment diabetic kidney disease].

The number of people with diabetes is increasing worldwide. Diabetes is the leading cause of end-stage renal disease. Diabetic kidney disease has been reported to occur in 25-40% of people with type 1 or type 2 diabetes. Recent studies have demonstrated that the onset and course of diabetic nephropathy can be significantly improved by intervention in early stage of the development of this complication. In this article we will review the current recommendations regarding the prevention and treatment of diabetic nephropathy.

Diabetic Nephropathies↗

PubMed2005

[LEAP (Lantus Early Access Programme) in Sarajevo].

LEAP is multicentric study in phase IV. The first aim was to affirm Lantus efficacy and safety in every day practice, in local conditions. The second aims were to verify therapy successful by measuring fast blood glucose (FBG) and HbA1c and to estimate patients' pleasure. Duration of study was 2 months. Lantus was administrated subcutaneously daily. Doses were individual. HbA1c was measured at the begining of therapy and at the last control. Blood glucose was measured every day. The study included patients who did not reach the control of glycemy, or patients with frequent hypoglycemic crysis, older then 6 year. LEAP study in Sarajevo included 114 patients. Fifty four patients (47%) were men, and 60 (53%) were women. 46% diabetics have type 1 of diabetes mellitus and 54% have type 2 diabetes mellitus. The results of study demonstrated statistically significant decreasing of FBG and HbA1c in both groups (I group--patients younger than 18 years and II group--patients older than 18 years), p<0.05. FBG in I group on the start of Lantus therapy was 9.9+/-3.9 mmol/l but on ending control was 8.7+/-4.4 mmol/l (p<0.05). HbA1c on start of therapy was 9.4+/-1.9%, but on end control was 8.0+/-1.8% (p<0.05). FBG in II group on start was 13.6+/-4.7 mmol/l but on finish was 7.3+/-2.9 mmol/l (p<0.01). HbA1c on start was 9.3+/-1.8% and on end was 7.2+/-1.2% (p<0.01). These results showed that the Lantus is very efficacious for good glycoregulation. Just for two months, HbA1c decreased for 2%. Undesirable effects were not registered. We concluded that Lantus is very safe. Most patients (89%) were satisfied with therapy.

Adolescent↗

PubMed2004

[Unilateral pheochromocytoma and adrenal gland hyperplasia].

Woman, forty two years old, has been hospitalized because of frequent headache, palpitation and tremor of lips with paroxysmal increase of blood pressure. The adrenals have examined. The status of the hormones has checked many times but showed increased values of VMA and 17-OH steroids only once. There is no possibility to measure the catcholamines. Analysis of other hormones has showed normal values except of paradoxal hGH increase during suppressive hGH test and hypoglycemia in OGTT test. The changes of the left adrenal, which size was 25x18 and 30x25 mm, have diagnosed by MRI of adrenals. It has been suspected microadenoma by MRI of pituitary gland. The left adrenalectomy has been done. During the surgery hypertension and tachyarrhythmia has occurred and treated by fentolamin and propranolol. No complications have been noticed after the surgery. The status of the adrenals hormones are in the normal range. Patohystological analysis has proved phcochromocytoma and hyperplasy.

Adrenal Gland Neoplasms↗

PubMed2003

[Amylin--a partner hormone to insulin].

This article will provide an overview of some of the known functions of a recently discovered hormone, amylin, a partner hormone to insulin. Studies indicate that amylin has a role in the postmeal glucose regulation through effects on glucagon secretion, nutrient delivery and food intake. Three hormones--amylin, glucagon and insulin--are a critical part of postmeal glucose regulation. The interaction of these hormones and their role in the regulation of postmeal glucose concentrations is the subject of this article.

Amyloid↗

PubMed2002

Medical aspects of the mass-scale civilian casualties at Sarajevo Markale market on August 28, 1995: triage, resuscitation, and treatment.

The siege of Sarajevo, which holds an important but tragic position in the history of war, lasted for more than 45 months, from April 6, 1992 to March 19, 1996. Shelling of the Markale city market on August 28, 1995, was the attack with the largest number of civilian casualties. There were 23 persons killed on the spot. Another 104 were injured, of whom 15 died immediately after the explosion or during surgery, and 4 died a week later. Transport to the hospital was provided mostly by other civilians and resuscitation on the spot was not attempted. The triage of the wounded was conducted at the Kosevo University Hospital Center and State Hospital by teams of surgeons and anesthesiologists. Out of 104 wounded, 94 were treated at several different Surgery Departments and the Emergency Department. There were 85 survivors among the wounded. This incident once again illustrates the importance of timely adequate triage and resuscitation after mass-scale injuring, which can increase the chances of survival.

Bosnia and Herzegovina↗