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Biomedical subjects

Iu A Akimov

Publications and source records attributed to Iu A Akimov.

At least 19 recordsLinked to original sources
PubMed1993

[Aldosterone receptors of the rat kidney in sciatic nerve injury and various mechanisms for their regulation].

It was shown, that the lesion of the sciatic nerve leads to disturbance of functioning of mineralocorticoid receptors of kidneys, which was expressed primarily as deterioration of the Na+ reabsorption in the kidneys ductulus cells. Simultaneous pharmacological blockade by propranolol's injections of neuroconductive and humoral pathways of transmission to the kidneys of pathological stimulus, caused in result of chronic irritation of sciatic nerve, prevents the development of disturbance in kidney's mineralocorticoid receptor apparatus functioning to a more extent, than the blockade of the neuroconductive pathway only. The obtained results point out that propranolol is a substance, which may prevent the development of neurogenic dystrophies.

Absorption↗
PubMed1976

[The effect of sodium amytal on the electrophysiologic properties of snail giant neurons].

Sodium amytal increased resting potential decreased and finally abolished action potentials and temporarily decreased input resistance of the neuron membrane. Simultaneously, the intracellular potassium content decreased, but sodium content was almost unchanged. These effects are suggested to be connected with changes in the membrane potassium permeability and with disturbances in the mechanisms of action potential generation.

Amobarbital↗
PubMedDate not supplied

[Effects of stress and types of the animal behavior on the binding aldosterone with the brain corticosterone receptors].

Specific accumulation of 3H aldosterone by corticosteroid receptors of the brain structures was determined in in vitro and in vivo experiments on rats of different behavioral types under the normal conditions and within two weeks after stress. In both variants, stress decreased binding of 3H aldosterone to corticosteroid receptors of the rat brain. Differences were found in binding of 3H aldosterone to corticosteroid receptors of the hippocampus, rather than the whole brain, in animals with different behavioral types both under normal conditions and after stress. The experimental results agree with the published data about involvement of the corticosteroid receptor system of the brain limbic structures in the formation of emotional reactivity in animals.

Aldosterone↗
PubMedDate not supplied

[Binding of aldosterone with cytoplasmic and brain nuclear corticosteroid receptors in rats with various types of behavior].

The results are given of in vivo experiments on the binding of (3H)aldosterone to corticosteroid receptors of the cytoplasm and nuclei in the brain structure in rats with different types of behavior. Differences were established in binding (3H)aldosterone to corticosteroid receptors of the hippocampus cytoplasm in the animals with different types of behavior both under the normal conditions and within two weeks after stress. Stress was shown to affect the binding of this hormone to corticosteroid receptors of the brain cytoplasm (without hippocampus and cerebellum). No differences were found in the binding of aldosterone to corticosteroid receptors of the brain nuclei after stress.

Aldosterone↗
PubMedDate not supplied

[The role of beta-adrenoreceptors in pathogenesis of neurogenic dystrophies].

Sciatic nerve damage led to a defective functioning of the renal mineralocorticoid receptors due to the disturbed neurotrophic supply of this organ: the reception of distorted nervous stimuli. The pharmacological blockade of both the neurotransmitter and the humoral pathways of the pathological stimuli from the damaged nerve to the kidney prevented the development of trophic disturbances as tested by the state of the renal mineralocorticoid receptor system. At the same time, the pharmacological stimulation of the sympathetic nervous system leads to an even more defective aldosterone reception by the kidney. Propranolol exerted an antidystrophic effect in the case of local damages of the nervous system and, thereby, prevented the development of neurogenic dystrophies.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

[Influence of unilateral nephrectomy on aldosterone receptors in the remaining kidney in rats].

It was shown that the 30th day of compensatory kidney hypertrophy arising as a result of unilateral nephrectomy was accompanied by an increased binding of the mineralocorticoid hormone aldosterone by cytoplasmic receptors of the tubule cells of the remaining kidney. The transfer of aldosterone from cytoplasmic receptors to the nuclear receptors increased in the tubule cells of the hypertrophied kidney. This suggests that at the early stages hypertrophies are expressed as adaptive phenomena and phenomena related to intensified functioning of the organ fulfilling the double load.

Adaptation, Physiological↗