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Iu A Morozov

Publications and source records attributed to Iu A Morozov.

At least 19 recordsLinked to original sources
PubMed2006

[Alterations in certain indices of the haemostasis system following aortic surgery].

MATERIAL AND METHODS: A total of 24 patients were examined after surgery on the thoracic or abdominal aorta. Depending on the level of the aortic clamping at the main stage of the operation, the patients were subdivided into three groups: Group One was composed of 7 patients with aortic coarctation in whom the level of artery clamping was located just below the subclavian artery, Group Two comprised 7 patients with an aneurysm of the infrarenal aortic portion, with the clamp applied immediately underneath the renal arteries, and Group Three consisted of 10 patients with type IV thoracoabdominal aortic aneurysm according to Crawford's classification, with the artery being clamped above the diaphragm. The studies were carried out at the following stages: before and at the end of surgery, then 6 hours thereafter, and at 24 hours postoperatively. RESULTS: The alterations in the indices of plasma-thrombocytic haemostasis at all the stages were insignificant and did not differ reliably between the groups. In Group One patients, the time of XHa-kallikrein-dependent fibrinolysis (XIIaKDF) at the end of the operation was found to be within the range of the normal values(657.5+/-92.3 s) and had no statistically reliable differences from the baseline value (612.0+/-63.7 s). After 6 hours and on day 1 after the operation, we observed inconsiderable inhibition of the fibrinolytic activity (903.0+/-142.3 and 848.9+/-149.5 s, respectively). In Group Two patients at the end of the operation, we registered a statistically reliable, as compared with the baseline value, shortening of the time of XIIaKDF (from 990.0 +/-81.0 to 510.0 +/- 103.6 s, p<0.05). However, the subsequent stages of the follow-up revealed a dramatic decrease in the fibrinolytic activity (to1.388.0+/-183.1 s). Group Three patients demonstrated a considerable activation of fibrinolysis at the end of the operation (348.2 +/-48.5 s), which was noted to remain unchanged during the first 24 postoperative hours, with the alterations in the D-dimer's concentration in patients of all groups at the stages of observation being of a unidirectional pattern, i. e. increasing maximally after 6 hours to be then decreasing on the first 24 hours after the operation. CONCLUSION: To prevent postoperative haemorrhage associated with hyperfibrinolysis in aortic operations, it is necessary to administer antifibrinolytic drugs with due regard for the level of aortic clamping.

Adult↗
PubMed2006

[Influence of extracorporeal circuits surface on hemostasis system during off-pump surgeries].

It is demonstrated that special surface of extracorporeal circuit promotes reduction of artificial circulation negative influence on hemostasis system. During artificial circulation coating "duraflo" gradually loses its protective characteristics due to washout of heparin molecules from the surface of extracorporeal circuit, whereas chemical link between heparin and protein in "safe-line" coating is more stable. The results of the study demonstrate no advantages of heparin coating of extracorporeal circuits over protein one. Finally, all the advantages of extracorporeal circuits with "safe-line" coating lead to a decrease of postoperative blood loss.

Assisted Circulation↗
PubMed2005

[Prophylaxis of tuberculosis with BCG vaccine in children from contact and from unknown contact].

The quality and efficiency of immunoprophylaxis against tuberculosis have been studied in 563 children, by estimating the vaccination BCG signs. The children who have familial contacts and have been rather fully (92.3%) and effectively inoculated with BCG vaccination and in whom skin scars, 4-7 mm in diameter, have formed are at a high risk of tuberculosis due to massive infection in the bacterial isolation foci. Inadequate immunobiological defense reactions promote the progression of endogenous infection and the development of active tuberculosis in the vast majority (67.8%) children who have unestablished and unvaccinated or ineffectively vaccinated with BCG, infected under the occult bacterial isolation conditions mainly in the families where the adults have residual pulmonary changes and hypersensitivity to tuberculin the absence of immunobiological defensive reactions is the major risk factor for active tuberculosis.

Adjuvants, Immunologic↗
PubMed2005

[Effects of features of extracorporal circuits on thrombocyte hemostasis, the fibrinolysis system, and development of hemolysis].

The article contains data which demonstrate that use of extracorporal circuits with special coating ("safe-line" and "duraflow") improves preservation of thrombocyte functional activity, and lowers activation of the fibrinolysis system in postoperative period, which results in decrease of postoperative blood loss. Use of heat exchangers with polypropylene coating is less traumatic to blood cells, and thus lowers frequency and degree of hemolysis.

Blood Platelets↗
PubMed2005

The platelet componentof hemostasis in aortic surgery.

The lack of significant changes in the count and function of platelets in aortic surgery without use of cardiopulmonary bypass (CPB) confirms that factors of extracorporeal circulation exert a remarkable adverse action on the platelet component of hemostasis. In operations performed under hypothermic perfusion or circulatory arrest, disorders of the platelet component even in case of the use of 2 mln. CIU trasylol (aprotinin) are most pronounced which gives rise to excessive postoperative blood loss in the given patient group. It may be assumed that the increase of the dose of trasylol up to 6 mln. CIU will allow, owing to its cytoprotective action, preserve as well as possible the quantitative and qualitative properties of platelets.

Aortic Aneurysm↗
PubMed2005

[Changes in hemostasis at aortic surgery under conditions of extracorporeal circulation].

This paper describes hemostatic changes in patients who had undergone aortic surgery under conditions of extracorporeal circulation. The changes in the hemostatic system are marked by the thrombophilic condition made up for activation ox blood fibrinolytic activity in the preoperative period. The basic amount of blood loss falls within the first 6 hours after operation. Prolonged hypothermic extracorporeal circulation and the high intraoperative blood loss (over 35 ml/kg bw) lead to an appreciable decrease in antithrombin III and protein C activity which results in activation of disseminated intravascular blood coagulation in the early postoperative period and ineffectiveness of heparin therapy. Secondary hyperfibrinolysis together with combined thrombocytopenia and platelet dysfunction are the basic causes of higher than usual bleeding in patients after aortic surgery under conditions of extracorporeal circulation.

Antithrombin III↗
PubMed2004

[Hemorheological changes during mammary coronary bypass grafting].

Hemorheological studies were performed in 44 patients subjected to mammary coronary bypass surgery during induction of anesthesia, at initiation of cardiopulmonary bypass, at the end of operation, on the 1(st) and 2(nd) or 3(rd) postoperative day. Methods included determination of whole blood and plasma viscosity with estimation of suspension stability and calculation of Caisson viscosity and fluidity limit. Rigidometry was used for assessment times of linear (T(1)) and three dimensional (T(2)) aggregates formation, final aggregates dimensions, total hydrodynamic strength of aggregates (beta), index of strength of especially large aggregates. Indexes of aggregation and deformation of erythrocytes were also calculated. Cardiopulmonary bypass was associated with lengthening of T(1) and shortening of T(2), increase of aggregates dimension and their hydrodynamic strength beta and lowering deformability of erythrocytes. By the end of operation increase of difference between Caisson and asymptotic viscosity was noted. Postoperative period was characterized by improvement of deformability of erythrocytes, prolongation of T(2), increases of aggregates dimension, their hydrodynamic strength beta, and fluidity limit. Thus measures of intensive therapy should be directed at correction of disturbances of rheological properties of blood with consideration of their changes specific for cardiosurgical patients.

Blood Viscosity↗
PubMed2003

[Hemorheological changes at reconstructive operations on the aorta].

Fifteen patients who had undergone aortic reconstructions were examined. Hemorheologic studies were performed at the following stagest initial anesthesia, the end of operation, the early postoperative period, and the 2nd-3rd days after operation. A study was made of blood viscosity at a shift rate 5-300 s(-1), of suspension stability, caisson viscosity (CV), and the yield stress (YS). The back light diffusion intensity was recorded on the erythroaggregometer ADE=5 (Russia) to evaluate the time of linear aggregate formation (T(1)), the time of three-dimensional aggregate formation (T(2)), characteristics of the end size of the aggregates (Ampl), total hydrodynamic strength of the aggregates (Beta), strength index of especially large aggregates (Ia((2,5))). The index of erythrocyte aggregation (IEA) and the index of erythrocyte deformation (IED) were also computed. Initially, the normal blood viscosity values were marked. However, in the early postoperative period, their values returned to the preoperative level. In patients with complications, blood viscosity appreciably rose, exceeding the preoperative parameters. At the end of operation there was a decrease in erythrocyte aggregation, especially due to the TT(1) and Ampl rise, while beta dropped. In the postoperative period, patients without complications demonstrated the growth of erythrocyte aggregation but Ampl of cell aggregation diminished. In the postoperative period, patients with complications showed a considerable intensification of erythrocyte aggregation due to the rise of Ampl, Beta and Ia((2,5)). Toward the end of operation a decrease of plasma viscosity was revealed in the presence of GV rise. In the postoperative period, patients with complications demonstrated the growth of plasma viscosity concurrently with CV lowering. Toward the end of operation the YS increased. However, in patients with the uncomplicated postoperative period, the magnitude of this parameter dropped and reached permissible values in the given patient group whereas in patients with complications, the YS remained significantly high.

Aortic Aneurysm, Abdominal↗
PubMed2003

[Efficacy of BCG vaccination].

Adults born in 1961-1962 and later were found to have skin vaccination marks by 3 times more less those born before this period. The high risk of diseases in young individuals from the family contact inoculated with BCG vaccine was due to massive superinfection. The incidence of tuberculosis in individuals under latent tuberculous infection is promoted by no or low-grade BCG vaccination.

Adolescent↗
PubMed2002

[Post-tuberculosis changes in the lung and tuberculin sensitivity in risk group adults].

There was a consecutive reduction in the incidence of residual changes in the lung and tuberculin hypersensitivity, which coincides with the periods of using different BCG vaccination methods in adults at risk for tuberculosis. In persons who were born in 1961-1962 or later when intracutaneous administration was used, these figures were 3.4 and 3.9 times lower than in those born before 1961-1962. The incidence of residual changes, tuberculin sensitivity in adult examinees were greater than the similar parameters in the general population. To detect and to follow up persons of these groups are pressing for stabilization of the epidemiology of tuberculosis.

Adolescent↗
PubMed1995

[The physicochemical properties of molsidomine preparations and their efficacy in treating IHD and circulatory failure].

Molsidomine drugs corvaton and sidnopharm were assessed clinically, physicochemically and experimentally. Corvaton tablets contained more active substance but less cleavage products than sidnopharm ones. In experiment with acute transitory coronary insufficiency corvaton was active both during myocardial ischemia and in reperfusion. Corvaton showed antianginal effect in 70.3%, sidnopharm in 58.6% of cases. Both drugs produced a positive action on coronary and myocardial reserves in coronary patients with angina class I-III but did not affect hemodynamics. Oral sidnopharm induced side effects 4 times more frequently than corvaton. Corvaton tablets (single dose) activity lasted more than sidnopharm effect by 2.2 hours. Oral corvaton remained active 5.3 hours longer than the same intravenous dose.

Chemical Phenomena↗
PubMedDate not supplied

[Temperature regimen of extracorporeal circulation during aortocoronary bypass surgery].

The purpose of the study is to comparatively evaluate the impact of normo- and hypothermic perfusion on acid-base balance (ABB), gas blood composition, metabolic parameters, and hemostasis. Fifty patients undergone multiple aortocoronary bypass under extracorporeal circulation (EC) were examined. Twenty four patients and 26 (Groups 1 and 2, respectively) had been operated on under normo- and hypothermia. The groups did not differ in age, body weight, the duration of an operation, the number of shunts, the time of EC, and myocardial ischemia. ABB, gas blood composition, the concentrations of hemoglobin, lactate, fibrinogen, prothrombin time, thrombin time, activated partial thromboplastin time, activated coagulation time, blood coagulation time as described by Leigh-White, the count of platelets, and ADP-induced platelet aggregation in the early postperfusion and postoperative periods, following 24 and 48 hours after surgery. There were no significant differences in the values of ABB, gas blood composition, blood lactate levels in patients from both groups. However, metabolic acidosis, elevated blood lactate concentrations were more frequently encountered in Group 2 patients, which suggests that hypothermia prduces a more aggressive effect on systemic homeostasis. Impact of normo- and hypothermia on the coagulative link of homeostasis was not revealed. Nevertheless, hypothermic EC halved the functional activity of platelets, which has a substantial effect on the size of postoperative blood loss.

Acidosis↗
PubMedDate not supplied

[Intensity of parasitic contacts in the colonies of large gerbils under conditions of different population density of the animals and their fleas].

In the period from April to May and September to October of 1967--1973 in the Mujun-Kum a radioactive tracing of great gerbils was carried out. In all 225 tests were conducted. The greatest intensity of parasitic contacts between the animals was noted at their average quantity. Its further rise does not result in the increase of the parasitic relations. If the number of fleas is high the parasitic contacts level even at the relatively low number of great gerbils is usually high enough for a further passing of the plague microbe. If the number of both fleas and great gerbils is low the parasitic relations provide but not always an agent transmission.

Animals↗
PubMedDate not supplied

[Impaired hemostasis as a cause of intensified bleeding after heart surgery with extracorporeal blood circulation].

The paper contains the results of a retrospective analysis of causes for an intensified bleeding in patients operated on the heart with artificial blood circulation. An affected hemostasis plasma chain, i.e. insufficiency of blood coagulation factors due to hemodelution, hypofibrinogenemia etc., provoked the above disorder in 39% of patients with a higher postoperative bleeding. Additional reasons for the impaired hemostasis chain included: the "heparin-rebound" phenomenon (3.4%), activation of the secondary fibrinolysis (3.4%) and disseminated intravascular coagulation (DIC) (0.14%). Finally, an undiagnosed inadequate surgical hemostasis provoked an intense bleeding in 19.5% of cases.

Blood Coagulation Disorders↗