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Biomedical subjects

Iu A Poliaev

Publications and source records attributed to Iu A Poliaev.

At least 19 recordsLinked to original sources

[Hemostatic provision of surgical treatment of juvenile angiofibromas of the skull base in children].

For three years we operated sixty two 7-16-year-old children for angiofibroma of the base of the skull. To reduce the risk of massive intra- and postoperative bleeding, we used preoperative endovascular occlusion of the vessels carrying blood to the tumor. In addition to preventive administration of vicasol, ethamsilate, dicinon and transamine, we used highly effective hemostatic drugs tahocomb and novo-seven intraoperatively in case of massive blood loss. Neither lethal outcomes nor complications occurred in children during removal of angiofibromas of the base of the skull.

Adolescent↗

[Lowering of nephropathy risk during angiography procedure. What are choice criteria for the radiocontrast media?].

The paper analyses current data of monomer and dimmer iodine-containing radiocontrast agents used for diagnosis of cardiovascular diseases and radiovascular interventions. Considering the risk factors of nephropathy as the most common and threatening complication of radiocontrast agents the authors conclude that non-ionic monomers are the most advisable as they demonstrate optimal balance of viscosity, water solubility, osmolality and diagnostic effectiveness.

Aged↗

[Use of ultra high-frequency electromagnetic fields in pediatric surgery].

The procedures associated with the application of a super-frequency electromagnetic field (SFEMF) are being introduced into a therapeutical process in their various modifications at the Pediatric Surgery Hospital of Russian State Medical University. This has been preceded by enormous experimental work aimed at evaluating the potentialities of SFEMF for potentiation of cryogenic exposure and for individual use for endovascular occlusion and local hyperthermia. A total of 947 patients were treated with SFEMF from 1979 to 1990. The largest group included children with hemangiomas of various site (n = 465) and those with cheloid scars (n = 395). Thirty-one patients underwent intravascular coagulation with SFEMF in the treatment of arterial and venous malformations and 31 patients were treated for pigmentary spots of various site with SFEMF + cryodestruction. Local hypothermia was performed in 25 children with extensive hemangiomas of the face and neck with SFEMF. The total therapeutical benefits reached 98%. For these purposes the authors used a Plot routine apparatus, 915 mHz, with a set of contact and special emitters. The experience with SFEMF in pediatric surgery suggests that it is highly effective and the trend is promising.

Animals↗

[Endovascular occlusion of the spleen in pediatric practice].

A procedure has been developed for partial X-ray endovascular occlusion of the spleen in children. Splenic occlusion has been performed in 74 patients with various blood diseases and portal hypertension for 4 years. Indications for partial "disconnecting" of the splenic parenchyma have been identified depending on a specific disease. Its low traumatism, prevention of septic complications by using selective intestinal flora decontamination and choosing antibiotics at an individual level allow splenic occlusion to be made in young children. In patients with portal hypertension, partial splenic occlusion leads to decompression in the portal vein system and improves blood ejection along the natural vascular anastomoses.

Adolescent↗

[Ultravist - drug of choice for radioopaque studies in children with renal disfunction].

The nonionic radioopaque ultravist and the high-molar radioopaque verograffin were studied for their effects on the blood osmotic status of children with lower renal concentrating function. A total of 36 children aged 8 months to 12 years who had pyelonephritis, hydronephrosis and renal injury at their acute stage were studied angiographically under general anesthesia. The radioopaque was injected in a mean dose of 2 ml/kg for 2-3 sec. Ultravist was found to have a less osmotic action on the blood osmotic status than did verograffin. The changes in the detectable major blood osmotic parameters: sodium, potassium, glucose, urea, creatine were less pronounced. Plasma osmolality was moderately increased with ultravist and much higher than its normal values with verograffin at min 1 after its administration and at hour 2 of the study. Ultravist is preferable as a radiopaque used in children with decreased renal concentrating function.

Acute Disease↗

[Use of intra-arterial chemotherapy in the treatment of malignant tumors in children].

Transcatheter arterial chemotherapy has been perfected in the treatment of 66 patients with various severe malignant tumors. A total of 75 arterial cytostatic injections were made, out of them 57 were given in primary tumors and 18 in tumor metastases. The children's age ranged from 1 to 14 years. High arterial therapeutic doses in combination with extracorporeal blood purification by hemosorption in the treatment of hepatic metastases yielded 100% efficiency. Prolonged arterial chemotherapy for pulmonary metastases provided an excellent therapeutic effect. Thus, 75 arterial injections of cytostatics gave rise to 32% of complete remissions, 48% of partial remissions. There was no benefit in 20% of cases. Adverse reactions were absent.

Adolescent↗

[Portal hypertension in children: venous shunting in the early childhood].

Operations were carried out on 98 children with extrahepatic portal hypertension and on 6 with intrahepatic block and no signs of hepatocellular insufficiency. Mesenterico-caval H-shunt was formed in 78 children with the use of the internal jugular vein as the insert. The remaining children underwent formation of mesocaval anastomosis (8), distal spleno-renal shunt (4), portocaval anastomosis (1), Sugiura's operation (7). Among the operations 68 were planned, 12 emergency, and 18 preventive. The average age of the children was 6.5 years; 31 were under the age of 5 years and 19 under 3 years of age. The youngest child was aged 10 months, the H-shunt was successful. The results of the operation: thrombosis of the shunt 0%, portosystem encephalopathy 0%, recurrent hemorrhage 0%, lethality 1%. This is evidence of the expediency of performing shunting operations in early childhood.

Child↗

[Roentgenologic endovascular occlusion of the spleen in the treatment of hereditary spherocytic hemolytic anemia in children].

Roentgenoendovascular occlusion of the spleen has been suggested for the treatment of children with hereditary spherocytic hemolytic anemia as an alternative to splenectomy. The operation was conducted in 8 children aged from 1 to 11 years. Selective decontamination of the intestine was used for prevention of inflammatory complications. Occlusion of 60% of the splenic parenchyma results in a stable clinico-hematological effect and can be performed as a single stage. Young children could be operated on by this method.

Angiography↗

[Osmolality of contrast media--a risk factor in radiological endovascular procedures in children].

The study was conducted in 90 children aged from 5 months to 14 years during radiologically-guided endovascular (RIV) interventions with bolus injection of radiocontrast agents (RCA) in a dose of 2-3 ml/kg for 2-3 sec. High-osmolality RCA were used in 80 children, an nonionic low-osmolality RCA omnipaque-300 in 10 children. Injection of RCA bolus was attended by marked acute disorders of blood colloidoosmotic equilibrium (COE) which depended on the initial status of the latter and were greater when high osmolality RCA were used. On the basis of the study results, the authors developed and tested a method of modulator infusion therapy with consideration for the initial blood COE (hyper-, normo-, hypoosmolality). The suggested therapy makes it possible to reduce the degree of blood COE disorders considerably and prevent the development of complications associated with disturbed osmoregulation.

Adolescent↗