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Biomedical subjects

Iu A Zozulia

Publications and source records attributed to Iu A Zozulia.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Methodology of surgical intervention for meningiomas of the medial portions of the wings of the sphenoid bone].

A procedure employed in removing meningiomas of the ala parva and of meningiomas affecting simultaneously ala parva and ala magna is described. Materials derived from operative interventions in 78 patients are studied. The application of the microsurgical technique in separating meningiomas from basilar arteries made it possible to improve the effectiveness of operative interventions. The overall post operative lethality comprised 24.3 per cent.

Brain Neoplasms↗
PubMedDate not supplied

[Role gene expression changes in development of human brain gliomas].

The identification and characterization of genes either induced or repressed in human brain tumors are important in understanding the mechanism of tumor initiation and progression, stages of malignancy, in developing new approaches to the diagnosis and treatment of tumors. In this paper, differential hybridization of arrayed human fetal brain and postnatal brain and postnatal brain cDNA libraries revealed differences in the rate of hybridization signals with total cDNA probes of the human brain and glioblastoma multiforme for more than 150 cDNA clones. Sixteen nucleotide sequences with changed contents in tumors were identified by repeated differential hybridization of the cDNA clones selected by primary screening with the same total cDNA probes of the human brain and glioblastoma multiforme and by Northern-hybridization of RNA samples from the human and glial tumors. The results of an analysis of the increased expression of the gene encoding apolipoprotein E. DNA-binding protein B, mitochondrial (16S and 12S) and cytoplasmic 28S rRNAs, Alu-containing transcripts, inactivation of cullin 1 gene and potential tumor suppressor gene TSC-22 are described.

Alu Elements↗
PubMedDate not supplied

[Experience with the use of intravascular interventions using a balloon catheter for several types of cerebral pathology].

Detachable balloon catheters were used during 38 intravascular procedures in 25 patients with vascular lesions and tumours of the brain. Permanent balloon occlusion of the cavernous part of the internal corotid artery or a reconstruction of this portion of the carotid artery, with its function preserved, was performed in patients with carotid-cavernous fistulas. In arterio-venous aneurysms one or two afferent vessels were occluded, while in cases of arterial aneurysm the latter was blocked itself. In cerebral neoplasms balloon catheters were used to precise the blood supply sources of the tumor, to occlude the vessels supplying meningiomas, and to perform intravital staining of the glial tumors. Positive results were obtained in 24 of the 25 patients. One patient died of middle cerebral artery thrombosis. The method of catheterization and occlusion of cerebral vessels with the aid of balloon catheters proved effective in the examination and treatment of patients with some vascular lesions and tumors of the brain.

Arteriovenous Fistula↗
PubMedDate not supplied

[Meningiomas of the 3d cerebral ventricle].

Meningiomas of the third ventricle, especially those located in its anterior part, are a rare occurrence. Two patients with meningiomas of the third ventricle are described. In one of them the tumor was removed successfully. Pneumoencephalography and positive ventriculography are of decisive importance in the diagnosis of these tumors. Analysis of the data in the literature and the authors' personal observations shows that timely removal of these tumors with the use of rational approaches and microsurgical techniques may yield satisfactory results.

Adult↗
PubMedDate not supplied

[Laser microsurgery of brain tumors].

The authors report on a fundamentally new laser method of removal of brain tumors. The operation was carried out with a Soviet-produced surgical laser Sayany-MT (power of 60 W) interlocked with an operating microscope. Eighty-five operations were conducted by means of laser techniques. The use of the surgical carbon dioxide laser in neurooncology makes it possible to improve the conditions for performing the neurosurgical intervention and insures its radical character and a less injurious effect.

Brain↗
PubMedDate not supplied

[Controlled arterial hypotension using nitroglycerin in brain surgery].

Artificial hypotension induced by 0.01% nitroglycerin solution was applied in 60 operations on the brain. It contributed to the creation of optimum conditions for radical removal of tumors and exclusion of vascular aneurysms, reduction of blood loss, and a decrease in the number of blood transfusion. The efficacy, adequate control, safety, and attainability of the method allowed it to be recommended for use in neurosurgical practice when necessary.

Brain Neoplasms↗