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Iu D Parfenov

Publications and source records attributed to Iu D Parfenov.

34 records · Page 2Linked to original sources
PubMed1984

[Analysis of uterine sarcoma induced in mice in terms of the two-staged development of tumors].

The results of combined treatment of CBA female mice with 1,2-dimethylhydrazine (DMH) and estradiol dipropionate (EP) are discussed in terms of a two-stage carcinogenesis hypothesis. 20% of mice treated with DMH alone developed uterine sarcomas. EP given after the cessation of DMH-treatment increased sarcoma incidence as high as 60.6% (5 micrograms EP) or 66.7% (10 micrograms EP) and significantly decreased the time of the first tumour appearance. From the standpoint of the two-stage carcinogenesis it is considered possible for EP to influence the tumour-initiating stage.

1,2-Dimethylhydrazine↗
PubMed1981

[Effect of age on induction of intestinal tumors in mice by 1,2-dimethylhydrazine].

1,2-Dimethylhydrazine was administered subcutaneously in a dose of 8 mg/kg bw to 2-, 8- and 12-month-old female CBA mice for 25 weeks. The animals were serially killed 26-35 weeks after the beginning of treatment. The incidence of colon tumors in 2-month-old mice was always significantly lower (P less than 0.001) than in 8- or 12-month-old mice. The incidence of tumors with invasive growth in 12-month-old mice was significantly higher (P less than 0.05) than in 8-month-old mice. Mathematical evaluation allowed the conclusion about the 1.8-fold shortening of the colon tumor latency period in old mice as compared to the young mice.

1,2-Dimethylhydrazine↗