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Biomedical subjects

Iu E Mikhaĭlov

Publications and source records attributed to Iu E Mikhaĭlov.

At least 19 recordsLinked to original sources
PubMed1999

[The lipid profile in patients with obesity who have undergone vertical gastroplasty].

The effect of vertical banded gastroplasty (VBG) on the lipid profile in obese patients is considered. The antiatherogenic effect of VBG and of the following weight loss consists in significantly decreased plasma triglycerides, increased content of high-density lipoproteins and decreased atherogenic coefficient. Patients with hypercholesterolemia have significantly lower total plasma cholesterol by the period of the body mass stabilization. The effect of VBG is compared with that of other methods of correction of dyslipidemia. The possibility to improve this effect is also discussed.

Adult↗
PubMed1997

[A new method for urea detection in biological fluids].

A modified urease hypochlorite method for measuring urea in biological fluids is described. Its novel feature is the use of 4-hydroxycoumarin as ammonia acceptor. This compound has never been used for this purpose, and it has a number of advantages over traditional phenol and its derivatives: the measurement is performed in just two steps, the compound is nontoxic and used in low concentrations, and the accuracy of measurements is higher due to decrease of the systemic error. Results of urea tests with the new kit are presented. The kit contains ready-to-use components in tablets and stabilized concentrated solutions of sodium hypochlorite and alkali. The characteristics of the kit are as follows: linearity of determination up to 25 mmoles per liter, deviation from linearity no more than 7%, and sensitivity up to 0.7 mmoles/liter.

Biological Assay↗
PubMed1989

[Enzyme and isoenzyme tests in the diagnosis of myocardial infarct during aortocoronary bypass].

The authors assess the diagnostic value of several enzyme and isozymic tests used in the diagnosis of myocardial infarction in aortocoronary shunting (ACS): the diagnostic sensitivity and specificity, as well as the significance of both positive and negative results, and the diagnostic efficacy of every test have been estimated. Ninety-one patients subjected to autovenous ACS have been examined for the total creatine kinase (CK), lactate dehydrogenase (LDH), aspartate and alanine aminotransferase activities, and for the activities of CK and LDH isozymes. The results evidence a high diagnostic value of CK and LDH isozymes measurements. A comprehensive study of these isozymes is a reliable criterion of the diagnosis of myocardial infarction. If myocardial infarction in ACS is diagnosed on the basis of the total enzymic activities, measurements of the transaminases and LDH are advisable; investigation of CK total activity is of poor informative value.

Clinical Enzyme Tests↗
PubMed1989

["False-positive" cytologic diagnoses].

In a series of 30,000 cytologic examinations carried out in patients with lung pathology, 20 results were considered false-positive for cancer. However, in 5 of them, malignancy was subsequently confirmed. These data were analysed to identify patterns of lung cancer in which cytologic samples are likely to be misinterpreted as false-positive.

Adenocarcinoma↗
PubMed1976

[Study of rat erythrocyte superoxide dismutase activity during a toxic regimen of interrupted hyperbaric oxygenation].

Development of toxic manifestations in rats under conditions of hyperoxia was accompanied by a significant lowering of the rat erythrocyte superoxide dismutase activity. The incubation of control rats hemolysate with hydrogen peroxide (10(-3)M) or with kumole peroxide (1.6 10(-4)M) also led to pronounced fall of the initial erythrocyte superoxide dismutase activity. As supposed, the lowering of the erythrocyte superoxide dismutase activity under hyperoxia could be due to the formation of peroxidation products.

Animals↗
PubMedDate not supplied

[Use of lornoxicam for analgesia in the early postoperative period].

Lornoxicam was used for analgesia in 64 patients on days 1-2 after extensive interventions. The drug efficiency and safety were evaluated depending on the dose and route of administration. Intravenous infusion of lornoxicam in a daily dose of 24 mg (basic therapy) did not involve the use of opioids in 35% patients and its analgesic effect was higher than that of promedol monotherapy. Combined therapy with lornoxicam and promedol allows reduction of promedol dose by 25-50% and the incidence of untoward effects by 27-44%.

Adult↗
PubMedDate not supplied

[The role of lactate acidosis and enzyme hyperactivity in evaluating hypoxic organ disorders in patients following cardiopulmonary byøass].

One hundred and fifty patients after cardiopulmonary bypass surgery have been examined. It has been shown that overall enzyme activity should be taken into consideration when determining the genesis of postoperative hyperenzymemia and diagnosing the topical (organic) damage. High lactate level (6-8 mmol/l) reflects profound circulatory hypoxia and shows a great likelihood of secondary damage of parenchymatous organs in patients after cardiopulmonary bypass surgery. Marked lactatacidosis combined with a 5-10-fold increase in enzyme activity in the early postoperative period is an unfavourable prognostic sign. Prolonged antagosan (trasilol) administration during cardiopulmonary bypass surgery may be one of the techniques preventing and correcting hypoxic organ damage.

Acidosis, Lactic↗