A manufacturing procedure has been developed to prepare the anthelmintic bromoxane as a finely divided dosage form. The maximum toxic dose of the drug was 1 g per kg mice body weight. Its therapeutic dose in sheep fascioliasis was 20 mg/kg.

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[The technology of manufacturing antiparasitic preparations. The development of a technology for obtaining the anthelmintic tegalid in a finely dispersed form and the evaluation of its antifascioliasis and antidicrocoeliasis activities].

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PubMedDate not supplied

[The technology for manufacturing antiparasitic preparations. 1. The development of a technology for producing the anthelmintic triklazan in finely dispersed form and the evaluation of its antinematodal, anticestodal and antitrematodal activities].

The authors describe the technology of preparing a new anthelmintic agent triclazan, N-(3,4-dichlorophenyl)-2-[(benzo-2,1,3-thiadiazole-4-sulfonyl)amino]-5- chlorobenzamide, finely dispersed (the particles size 4-8 mu). Triclazan is highly effective not only in hymenolepiasis and trichocephaliasis, as was shown previously, but in fascioliasis, monieziasis and intestinal nematodiasis of sheep as well.

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[The search for new antiparasitic agents. 16. A study of the anti-Fasciola activity of N-[(chloro-naphthyloxy)phenyl]benzamides].

The study was undertaken to examine the fasciolacidal activity of the agents G-1411, G-1423, and G-1439. Tested, G-1439 was chosen for detailed investigations as a non-toxic fasciolacide.

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PubMedDate not supplied

[The technology for manufacturing antiparasitic preparations. 5. The development of a technology for producing the anthelmintic triclonate and the evaluation of its therapeutic efficacy in monieziasis].

A procedure has been developed to manufacture the anthelminthic Triclonate. The agent was tested for the treatment of sheep's natural monieziasis infection and it was found to have a high activity.

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[The technology for manufacturing antiparasitic preparations. 7. Preparation G-1460 and its use for the treatment of monieziasis and intestinal nematodiases].

A procedure was developed for the synthesis of the anthelminthic G-1460. The therapeutical doses (20 and 25 mg/kg) of the agent were defined for the treatment of monieziasis and gastrointestinal nematodes on an individual basis.

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PubMedDate not supplied

[The technology for manufacturing antiparasitic preparations. 8. The preparation rilanid and its use for treating fascioliasis and intestinal nematodiases].

A procedure has been developed to prepare the anthelminthic Rilanide as a fine-dispersed formulation. The therapeutical dose of the agent in fascioliasis and intestinal nematodiasis is 60 mg/kg (for sheep), if given alone, and 100 mg/kg, if added to feed.

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