[Current classification of rickets in children (response to the discussion)].
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Biomedical subjects
Publications and source records attributed to Iu G Antipkin.
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Infants afflicted with rickets demonstrate a reduction in the blood content of vitamin K-dependent protein, osteocalcin, most pronounced in disease of medium gravity, in its calcipenic and phosphopenic varieties. It has been established that there is an inverse correlation between osteocalcin content and the level of parathyroid hormone and a direct correlation between osteocalcin content and the concentration of total and ionized calcium and calcitonin in the blood. It is suggested that measurement of blood osteocalcin in children may serve a diagnostic marker of metabolic disorders and mineralization of osseous tissue.
The development of experimental vitamin D deficiency in rats was accompanied by changes in cyclic nucleotides metabolism in the cortical part of kidneys, namely the increase in cyclic AMP synthesis and the decrease in cyclic GMP. The above changes appear in combination with marked deviations in calcium/phosphorus metabolism.
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