[Modeling in experimental toxicology studies].
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Biomedical subjects
Iu M Medvedev
Publications and source records attributed to Iu M Medvedev.
[Mathematical modeling of poisoning processes in hygienic research].
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[Sequelae of a drug block and the potential for pharmacological correction of the neuroeffector effects on the heart in reversible ischemia of varying duration].
The development of local reversible ischemia of the myocardium is characterized by the stereotyped time course of changes in the heat neuromediator content: predominant increase in the noradrenalin content in the hyperkinetic stage of the disease and fall in its content with concurrent increase in the acetylcholine content in the hypokinetic stage. Cardiac function changes accordingly. Partial blockade of M-cholino- and beta-adrenoreceptors leads to impaired balance of the neuroeffector influences on the heart under irreversible ischemia. The impairment is shown by more material changes in cardiac activity as compared to those induced by concurrent switch-off of the receptors. Pharmacological correction of sympathetic neuroeffector influences by means of myoephedrine increases heart resistance to its reversible ischemic alteration.
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