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Biomedical subjects

Iu P Gribunov

Publications and source records attributed to Iu P Gribunov.

17 recordsLinked to original sources

[Stewart-Treves syndrome--lymphangiosarcoma in sever lymphostasis of arm after mastectomy].

Stewart-Treves Syndrome ('STS) is a rare, extremely malignant and quickly progressing tumor. It is angiosarcoma developing in lymphostasis of an arm after radical mastectomy for cancer. The patient aged 80 years was followed-up, in whom STS had developed 19 years after radical mastectomy. Clinical diagnosis was confirmed by pathomorphological examination of dermal biopsy. Advanced age and severe associated diseases made it impossible to carry out specific therapy. The patient died of intoxication and increasing cardio-vascular insufficiency 9 months after the onset of the disease.

Aged↗

[A rare case of manifestation of reticulosarcoma by development of multiple cerebral hemorrhages].

Metastatic injury to the brain occurs very rarely in reticulosarcoma patients, presenting considerable difficulties for clinical diagnosis. Such an injury has not been reported in the neurological literature. The authors describe a case of the generalized form of reticulosarcoma with multiple metastases and secondary hemorrhages to the brain attended by blood breakthrough to the ventricular system. Difficulties are noted, occurring in differential diagnosis, and specific features of the clinical picture and pathomorphological alterations are described. In contrast to the primarily hemorrhagic manifestations in the brain, blastomatous proliferation in the visceral system (the gastrointestinal tract, lymph nodes) provoked appreciable necrotic lesions.

Adult↗

[Experience using the automated information retrieval system "Biopsy" in the pathology department of a general hospital].

Automatic information retrieval system (AIRS) "Biopsy" has been created on the basis of original programs and personal computer and tested for 3 years in the activity of the pathology department of a big multidisciplinary hospital. AIRS considerably increases the level of the labour organization and facilitates the overall and routine analysis of both biopsy material and the work of a department.

Biopsy↗

[Morphological study of the damaged myocardium in autopsies with previous ECG and blood enzyme test evidence of various clinical forms of ischemic heart disease during exacerbation phase].

Of 98 patients who died from myocardial infarction as evidenced by sectional and histological examinations, during their life 74 had had signs of extensive myocardial infarction (EMI), 11 had presented with small myocardial infarction (SMI), 10, focal myocardial dystrophy (FMD), 3, angina pectoris (AP). In the acute period, the highest values of hyperenzymia, CPK, MB-CPK, ACT, LDH1, LDH2, and enzyme ratios were revealed in EMI, the lowest ones were seen in AP; SMI and FMD stood midway. A significant moderate direct relationship was established between the maximum activity of CPK, MB-CPK, and LDH1 and the histological sizes of ischemic necrosis as documented by planimetry. It was suggested that the topography and site of ischemic lesion determined life-time ECG evidence of respective clinical forms of coronary heart disease during its exacerbation, and the severity of hyperenzymia governed necrotic mass.

Aged↗

[Correlation of wall thickness and the luminal diameter of the arterial vessels of the kidneys in hypertension].

The autopsy material was used to study the ratio of the wall thickness and the lumen diameter in arch and interlobular arteries and arterioles of the kidneys in patients with hypertension and in the control group. A statistical analysis revealed in interlobular arteries and arterioles of the age group of 30-49 years a slight but a significant shift of the parameter under study towards more severe degrees of involvement. This was confirmed by the frequency of different degrees of damage. No significant differences in changes observed in interlobular arteries and arterioles were found. This method is recommended for the study of the structural changes of intrarenal arteries.

Adult↗

[So-called medullary fibromas of the kidney].

This is the first description in the national literature of morphology of the so-called medullar fibromas of the human kidney which are considered to be hormonally-active (producing prostaglandines) tumours or tumour-like focal hyperplasias of interstitial cells of the kidney medullary layer.

Adult↗

[A method of determination of the accuracy of morphological diagnosis of surgical and biopsy material].

The accuracy of morphological diagnosis of 281 surgical samples and biopsy material was analyzed including 253 intrasurgical biopsies on frozen and paraffin sections and 26 television (out of sight) consultations in the "off-line" regime with subsequent control optical microscopy of paraffin sections. The indices of specificity, correspondance and sensitivity allow to have more objective assessment of the quality of life-time morphological diagnosis and can be considered as an obligatory component of annual reports of pathology departments and reports of clinical pathologists at professional certification.

Biopsy, Needle↗