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Biomedical subjects

Iu P Reznikov

Publications and source records attributed to Iu P Reznikov.

At least 19 recordsLinked to original sources
PubMed1998

[Antigliadin antibodies in the absence of celiac disease].

Antigliadin antibodies (AGA) mark celiac disease, but AGA are also encountered in IgA-nephritis, psoriasis, sickle-cell anemia, hepatic disorders, juvenile rheumatoid arthritis, autoimmune thyroidism and in persons who occupationally contact great amounts of wheat. AGA IgA and/or IgG were registered in 19 of 60 subjects (51 adults and 9 children) with various immunomediated diseases without symptoms of celiac disease: in 4 cases of chronic active hepatitis, in 2 of 4 cases of chronic persistent hepatitis, in 4 of 16 cases of rheumatoid arthritis, in 3 of 19 cases of IgA-deficiency, in 1 of 8 cases of SLE, in 2 cases of postvaccine reaction, in all the single cases of juvenile rheumatoid arthritis, focal scleroderma, macroglobulinemia. IgA only occurred in in 6 patients, IgG- in 6 patients, both IgA and IgG in 7 patients. The most pronounced positive reaction to AGA was recorded in 8-year-old girl with juvenile rheumatoid arthritis. The emergence of AGA in immunomediated diseases may be attributed to the response to food protein in pathological conditions and is often unrelated closely with celiac disease.

Adolescent↗
PubMed1996

[Monoclonal free light-chain immunoglobulins: their clinical interpretation].

23 cases of free light chains (FLC) occurrence in the blood and/or urine in the absence of monoclonal gammopathy are reported. Of them 15 cases were attributed to renal diseases associated with deranged catabolism of low-molecular proteins including FLC. In the rest cases FLC hyperproduction in autoimmune diseases was suspected to cause FLC appearance. No correlation was found between the amounts of FLC, creatinine, beta 2-microglobulin, light chains, kappa/lambda proportions.

Adult↗
PubMed1990

[Changes in the levels of serum proteins in patients with chronic obstructive bronchitis].

A new approach is suggested for evaluation of changes observed in serum levels of immunoglobulins, compliment components and proteinase inhibitors in subjects suffering from chronic obstructive bronchitis (COB). These levels were compared for COB patients (n-15) in remission and under aggravation of the disease. The comparison promoted a significant assessment of the shifts and their pattern for humoral defence factors. There appeared a correlation between concentration of some serum proteins and bronchial obstruction characteristics.

Adult↗
PubMed1990

[Atopic dermatitis. IV. The role of proteinase inhibitors in the pathogenesis, assessment of the severity and the prognosis of the disease].

Examinations of 59 patients with atopic dermatitis have revealed increased content of the major inhibitors of proteinases, a relationship between the patients' age and alpha 2-macroglobulin level in both the patients and the reference group normal subjects. Detection of correlations between alpha 1-proteinase inhibitor and serum IgE as well as between C1 inactivator and C3c have lead to a supposition on the contribution of proteinase inhibitors in the modulation of immune reactions. Clinical features of atopic dermatitis in alpha 1-proteinase inhibitor deficiency and in various blood serum IgE levels are discussed.

Adolescent↗
PubMed1990

[A possible variant of a false diagnosis of infection with the human immunodeficiency virus].

The authors describe a patient who demonstrated positive blood responsiveness to the nuclear antigens of human immunodeficiency virus (HIV) (p17, p31 and p55), observed steadily for 1 year and 4 months. The donor's disease history consideration made it impossible to include him in one of the known groups at risk for HIV infection whereas the lack of any changes in immunoblotting enabled one to exclude the diagnosis of HIV infection. The given case and other similar cases form the basis for introducing the second parallel screening during blood testing for HIV infection to bar the use of such blood for transfusion.

Adult↗
PubMed1989

[Atopic dermatitis. I. Characteristics of the clinical course and state of the immune status in relation to the initial level of serum IgE].

Altogether 97 patients with atopic dermatitis have been examined to follow this relationship, 72 patients presented with disseminated efflorescence, 25 patients with local rash. Measurements of immunoglobulins A, M, G, and D, of the C3c complement components, of the total and allergen-specific IgE C4, inactivators have been carried out, as well as of the total lymphocyte, B lymphocyte, and CD3+, CD4+, and CD8+ lymphocyte subpopulations; the lymphocyte response to ConA mitogenic stimulation has been also under study. The patients with normal and elevated levels of IgE differed by the clinical picture of the disease and by case histories, as well as by the immunity parameters and by the results of zaditen therapy. Cases with very low IgE levels may be indicative of alternative pathogenetic mechanisms.

Adolescent↗
PubMed1989

[Atopic dermatitis. II. The status of complement proteins and the pathogenetic role of anaphylatoxins C4a, C3a and C5a].

Eighty-eight patients with atopic dermatitis have been examined for the complementary proteins C3 (C3c), C3act., C4, C1inact. by radial immunodiffusion; in 36 of these patients anaphylatoxins C3a des Arg, C5a des Arg, and C4a des Arg have been radioimmunoassayed. Increased levels of C4a des Arg have been revealed in 50% of the examinees. C3a des Arg levels did not differ significantly from the reference values, and C5a des Arg level has been within the normal range in all the patients. C4a des Arg has been related to the severity of the skin inflammation and did not depend on the serum IgE content. C3 (C3c), C3act., C1inact. have been elevated and C4 reduced. These findings evidence activation of the complementary system in atopic dermatitis and indicate the role of anaphylatoxin C4a des Arg in the maintenance of the inflammatory reactions.

Adolescent↗
PubMed1988

[Place of carbohydrate antigens in the spectrum of protein tumor markers in patients with tumors at different sites].

Carbohydrate antigens (CA-19.9 and CA-125) levels were assayed in patients suffering rectal, ovarian, breast and hepatic carcinoma, severe recurrent hepatitis A, chronic persistent hepatitis B, hepatic cirrhosis and in cases of normal pregnancy. Patients with early-stage cancer usually failed to reveal the said antigens. This was also the case in some patients with clinically manifest tumor. Clinical application of said assay may improve postoperative monitoring cancer patients. Cancer was more frequently associated with increased level of CA-19.9 than with that of CA-125.

Antigens, Neoplasm↗
PubMed1986

[Beta 2-microglobulin in the blood serum and urine of patients with interstitial kidney lesions].

A study of the level of beta 2-microglobulin (beta 2-MG) in the blood serum and urine was conducted in 67 patients: 22 with chronic pyelonephritis, 13 with gout with renal lesion, 25 with chronic glomerulonephritis (5 without hyperuricemia, 20 with hyperuricemia) and 7 with amyloidosis accompanied mainly by renal lesion. A raised level of beta 2-microglobulin was found in the patients with chronic pyelonephritis, gout, latent glomerulonephritis with hyperuricemia, and in over half of the cases its raised level was found in the urine. The results obtained indicate a frequent and in some cases predominant involvement of the tubules as well as interstition in the patients with hyperuricemia.

Adult↗