Biomedical subjects

Iu S Egamov

Publications and source records attributed to Iu S Egamov.

4 recordsLinked to original sources

PubMed1993

[Sorption in the treatment of acute peritonitis (experimental study)].

The data on the effective use of the new sorbent KAY and the carbon sorbent "Volna" in the treatment of acute generalized peritonitis were compared. Endosorption with sorbent KAY was conducted on an experimental model of generalized peritonitis. It produced a favorable effect on the functional morphology of the peritoneum by leveling many morphological signs of general intoxication of the organism and in this way creating the conditions for a favorable outcome of the postoperative period. The studies showed that the use of sorbent KAY in the treatment of acute generalized peritonitis facilitates active restoration of the function of vital organs, significantly raises the efficacy of treatment, and shortens the period of in-patient treatment.

Acute Disease↗

PubMed1992

[Antibiotic therapy in acute diffuse peritonitis].

The pharmacokinetics and clinical efficacy of antibiotics administered by various routes in acute diffuse peritonitis were studied on 25 non-inbred dogs and potential of lymphotropic administration of the antibiotics through the mesentery of the small intestine in urgent surgical operations because of the diseases of the abdominal cavity was estimated. It was shown that the intra-mesenteric administration of the antibiotics was more efficient. In acute diffuse peritonitis it provided high therapeutic concentrations of gentamicin in the central lymph and lymph nodes of the abdominal cavity.

Acute Disease↗

PubMed1992

[An improvement in the combined treatment of acute peritonitis].

The object of the research was to study regional lymph circulation in abdominal organs in experimental acute peritonitis and determination of the possibility of including lymphotropic therapy in the complex of measures for the management of patients with acute peritonitis. Regional lymph circulation in the abdominal organs was studied in 45 unbred rats, the effect of various lymphostimulators of regional lymph circulation was studied in 35 rats. Lymphotropic therapy was applied in the complex treatment of 106 patients with acute peritonitis in the clinic. The results of the study showed that lymph circulation in the abdominal organs is markedly disturbed in acute generalized peritonitis, in view of which application of lymph therapy in the complex treatment of patients in the postoperative period is pathogenetically substantiated. Lymph therapy improves microcirculation, promotes early restoration of gastrointestinal activity, reduces the expenditure of antibiotics to one half and one fourth, and shortens the term of inpatient treatment.

Abdomen↗

PubMed1988

[Effect of opioid peptides on the lymphatic drainage of the pancreas in the rat and dog].

The effect of dalargin and some other ligands of the opioid receptors on drainage function of the pancreatic lymphatic system was studied in rats and dogs. In rats, dalargin (30-1000 micrograms/kg, subcutaneously) accelerated the elimination of Evans blue from beneath the pancreatic capsule in a dose-related manner. The effect of dalargin was attenuated by naloxone. Specific agonists of mu-, delta- and sigma-opioid receptors had no dalargin-like activity. In dogs, dalargin (60-80 micrograms/kg, subcutaneously) after the administration of Evans blue into the pancreas increased its concentration in the truncus lymphaticus and slowed down its penetration into the blood. Thus, dalargin accelerates the elimination of Evans blue from the pancreas due to the intensification of lymphatic drainage. The effect of dalargin was mediated by subpopulation of opioid receptors with which their certain selective ligands have but slight interaction.

Animals↗