[Simulation of cell renewal in the small intestine epithelium of intact and irradiated animals].
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Animals↗
Biomedical subjects
Iu V Gusev
Publications and source records attributed to Iu V Gusev.
[Simulation modeling of the initiation of tumor growth in continually renewed cell systems].
A discrete stochastic model of simulation of a cell renewal system is discussed. The model is based on a functional approach to the present-day concepts on the nature of processes of cell proliferation and differentiation as well as mechanisms responsible for integration of these processes. Due to application of specialized programming means of simulation (language GPSS /360) a complete functional pattern of maintenance of cell-population homeostasis in tissue was reproduced. Disturbances in certain mechanisms of intra-tissue regulatory system accompanied by formation of tumor growth foci were simulated experimentally.
Animals↗
[Simulation modelling of cell systems in definitive and developing tissues].
A review of simulation models of cells is provided, with a description of the basic methods of simulation. The deterministic and stochastic models of cell kinetics are considered on a few examples. A tendency has been revealed to applying the method computer reflection of the structure of heterogeneous cell systems. The utilization of specialized programmed languages of simulation is considered as promising.
Animals↗