[The participation of pancreatic enzymes in digestion in chronic enteritis and enterocolitis].
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Biomedical subjects
Publications and source records attributed to Iu V Linevskiĭ.
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Aspiration biopsy of the mucosa from the beginning of the jejunum was conducted in 43 patients with duodenal ulcer (during exacerbation) and in 15 normal subjects (control group). The biopsy sample was used to study the jejunum activity in providing the initial stages of triglyceride hydrolysis in the area of membrane and intestinal digestion. Monoglyceride lipase activity of biopsy sample homogenate was studied that provided the final stages of triglyceride hydrolysis. As a result of histological investigations of biopsy samples from 34 patients, chronic jejunitis (without atrophy) was diagnosed in 32 of them. Increased lipolytic activity providing the initial stages of triglyceride hydrolysis in the area of intestinal and membrane digestion, and decreased production of monoglyceride lipase by the jejunum have been recorded.
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Ultrasonic histogramme was studied in 35 patients with chronic pancreatitis and 20 donors, taken in the area of the head and body of the pancreas, as were levels of immunoreactive trypsin--fasting and after standard food load,--and C-peptide in blood serum on an empty stomach. To increase informative value and specificity of ultrasonic and radioimmunologic investigations an index has been suggested, based on the findings from histogramme and radioimmunity analysis.
As many as 12 patients with pseudotumorous chronic pancreatitis have been examined. While studying the functional state of the pancreas a conclusion was reached about a decrease in the organ's exocrine activity, with the hormone output remaining unaffected. Particular features of the immunity status in the patients are outlined. It is recommended that dynamic ultrasonic investigation and computerized tomography to the abdominal cavity and retroperitoneal space, transcutaneous puncture biopsy of the pancreas, should be used for the differential diagnosis with carcinoma of the organ to be made possible.
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