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Iu V Ponomarenko

Publications and source records attributed to Iu V Ponomarenko.

7 recordsLinked to original sources
PubMedDate not supplied

[Averaging results of site recognition can increase the accuracy of annotating the human genome].

A systemic approach is proposed, which makes it possible to increase the accuracy of recognition of functional sites in arbitrary DNA sequences. The approach is based on the Central limit theorem and consists in the averaging of a large number of recognitions of a particular site. To obtain a rather large number of recognitions within the framework of conventional methods of recognition, consensus, and frequency matrix, 20 novel oligonucleotide alphabets were used. The approach was used to study the binding sites of GATA-1 and C/EBP transcription factors. It was found that the averaged recognition of these sites is more precise than each of specific recognitions, which just follows from the Central limit theorem.

Base Sequence↗
PubMedDate not supplied

[Contribution of signals and antisignals in the mutational spectrum of the td-intron insertion site].

The insertion sites of the td-intron were studied. It was found that tetranucleotides W-30A-29W-28Y-27, V-19B-18W-17A-16 and A11W12A13W14 predominantly occur at normal sites (signals), and tetranucleotides Y-27W-26M-25G-24, V7B8W9A10 and Y15W16M17G18 occur more frequently at defective sites (antisignals). It was shown that antisignals make the site defective, by blocking its signals. The site becomes defective due to the distortion of signals at a large number of random substitutions, and due to antisignals when the substitutions are few.

Base Sequence↗