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Biomedical subjects

Iu V Zinov'ev

Publications and source records attributed to Iu V Zinov'ev.

At least 19 recordsLinked to original sources
PubMed1990

[Effect of fasting and elemental carbohydrate feeding on the liver resistance to the action of cytostatics].

To study the influence of cyclophosphamide and methotrexate on the function of isolated perfused liver, and the hepatoprotective effect of starvation and parenteral glucose feeding, the authors conducted 57 tests on the rabbit liver. It was established that addition of cyclophosphamide, and, especially, of methotrexate into the perfusate negatively affected the function of the isolated perfused liver. Parenteral glucose feeding produced a protective effect on the isolated liver against the detrimental action of both methotrexate and cyclophosphamide.

Animals↗
PubMed1987

[Effect of elemental nutrition and fasting on the resistance of the liver to ischemia].

The efficiency of the element nutrition with glucose and alvezin and fasting as means of the antiischemic defense was studied in 50 experiments in perfusion of the isolated liver on rabbits previously subjected to 18-20 minute heat ischemia. The parenteral administration of glucose and graded fasting were shown to be most effective for the antiischemic defense of the liver.

Amino Acids↗
PubMed1986

[Optimal anion composition of the perfusate for preservation of the liver].

The search for optimal concentrations of fumarate, malate, acetate, lactate, asparginate and sulphate in the perfusate was performed in 187 experiments with 2 h perfusion of the isolated rabbit liver at different temperature regimens of conservation. Nonlinear relation between the optimal anion composition of the perfusate and temperature of the liver conservation was found. The critical point in changes of the optimal concentrations of anions in the perfusate was shown to be 10-12 degrees C.

Animals↗
PubMedDate not supplied

[Study of the mechanism of erythropoietin effect on energy metabolism in the bone marrow].

In extracts of rabbit bone marrow cells was studied effect of erythropoietine on the activity of some enzymes (hexokinase, phosphoglucomutase, phosphohexoisomerase, lactate dehydrogenase, glucoso-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and NADP-reductase). The NADP-reductase activity was increased under the effect of erythropoietine; the activities of other enzymes studied was not altered.

Animals↗
PubMedDate not supplied

[Increase in the rate of anaerobic glycolysis as an index of hypoxia in hemorrhagic shock].

A rate of anaerobic glycolysis and the activity of several enzymes involved were studied in brain, heart, liver and small intestine of rabbits in hemorrhagic shock. In hemorrhagic shock at 45 mm of m. c. the rate of glycolysis was increased in liver tissue and intestine, at 35 mm of m.c.--in liver tissue, intestine and brain, at 26 mm of m.c.--in all the tissues studied. The enzymatic activity did not alter markedly. The possible mechanism of the increased rate of anaerobic glycolysis is discussed.

Animals↗