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Biomedical subjects

Iu V Zotov

Publications and source records attributed to Iu V Zotov.

At least 19 recordsLinked to original sources
PubMed2004

[Clinical and neurophysiologic aspects of surgical treatment of pharmacoresistant forms of epilepsy].

Surgical treatment of pharmacoresistant forms of epilepsy under neurophysiological monitoring is a key problem studied in A.L. Polenov Russian Neurosurgical Institute (Saint-Petersburg). A summary of long-term studies and main stages of surgical treatment development are presented. The indications and contra-indications, along with basic neurophysiologic strategic and tactic arguments of open and stereotaxic treatment of focal and generalized epilepsy based on neurophysiologic model which determines a role of epileptic focus, epileptic and inhibiting brain systems in spreading and arresting of seizure discharge at each disease stage are formulated. A program of clinico-neurophysiologic monitoring of temporal epilepsy in pre- and intraoperative periods is considered.

Anticonvulsants↗
PubMed1996

[The combined treatment of severe craniocerebral trauma taking into account the nature of the brain damages and the extent of the hypertensive-dislocation syndrome].

The intracranial pressure was measured in 95 patients with a severe cranio-cerebral trauma at the postoperative period. Four degrees of the hypertension-dislocation syndrome were established. The characteristic of operative accesses is given. Drainage of the ventricular system of the brain and anterior falxotomy were shown to be expedient. The estimation is given to the efficiency of dehydration therapy at the early postoperative period against the background of intracarotid and intravenous infusions of remedies.

Acute Disease↗
PubMed1990

[Changes in human cerebral cortex in various areas of concussion in severe cranio-cerebral injury].

In 23 patients with a severe cranial-cerebral trauma the operative material (pieces of the cortex, obtained from the destructive, transitional and relatively preserved zones in the bruise foci with crushing, localized in various lobules of the cerebral hemispheres) has been studied. From 2 h up to 9 days after trauma, changes, characterizing the state of the vascular bed, nervous and glial cells have been followed. In the external area of the transitional zone in 15 patients and in the relatively preserved zone in all the patients reversibly altered nervous cells predominate. Only in the destructive zone in all 23 patients and in the whole transitional zone in 8 patients neurons in all cortical layers are deeply injured and unviable. Certain considerations on differential surgical tactics, when treating the bruise foci with crushing at a severe cranial and cerebral trauma are presented.

Adult↗
PubMed1984

[Surgical treatment in severe forms of closed craniocerebral injury].

Modern principles of diagnosis and surgical treatment of traumatic intracranial hematomas, subdural liquor hydromas, foci of crushing of cerebral hemispheres and depressed fractures of bones of the cerebral fornix are presented including reference to general surgical and traumatological hospitals. New views to the formation of intracranial hematomas and subdural liquor hydromas are described.

Brain Concussion↗
PubMed1976

[Medical rehabilitation medical-disability expertise of patients with post-traumatic bone defect of the skull].

The authors analyzed the results of treating 171 patients with sequelae of brain trauma and defects in the bones of the cranial fornix. On the basis of repeated examinations disturbances of brain functions were detected in 94 patients. In the remaining cases the only reason for invalidity was the cranial bone defect. For purposes of cranioplasty different methods were used. The results of surgical treatment permit to claim that the operation of choice in closing the bone defect is cranioplasty by homobones. In alloplasty of the cranial bone defect and all the more so in homobone plasty, it is expedient to reconsider the medico-labour examination in this category of patients.

Adolescent↗
PubMed1976

[Frontal, or generalized, epilepsy].

The author studied the results of surgical treatment of 28 epileptic patients where the localization of the epileptogenic focus was on the medial surface of the hemisphere in the area of the frontal pole or on the lateral surface. Taking into consideration the theoretical premises, an analysis of literary data and the results of a comprehensive clinical study of patients the author comes to the conclusion that for a localization of the epileptogenic focus in the area of the pole and medio-basal parts of the frontal lobes primary generalized epileptic seizures and distant synchronous bioelectrical activity in the EEG without distinct focal changes are most characteristic.

Epilepsy↗
PubMed1975

[Alterations in several cerebral metabolic indices in patients with epilepsy].

The paper pertains to studies of some metabolic indices in the brain of 106 epileptic patients where fits were of a traumatical and inflammatory etiology and with the duration of the disease from 1-10 years. The examination revealed disorders of the reductive-oxidative processes and carbohydrate metabolism in the brain which were not related to the etiology of epilepsy. A disorder of reductive-oxidative processes were more expressed in focal nonconvulsive fits characteristic for temporal epilepsy. The authors point to a certain correlation between changes in biochemical indices and the duration of the disease.

Adolescent↗
PubMedDate not supplied

[Cranio-cerebral hypothermia and neuro-vegetative blockade in the systematic treatment of injuries to the skull and brain].

A method of neurovegetative blockade with and without cranio-cerebral cooling has been worked out to deal with patients with traumas of the cranium and brain of varying severity. Indications for application of the neurovegetative blockade and cranio-cerebral cooling, their intensity and duration have been defined. The application of these methods within the framework of a complex purposeful treatment of severe cerebrocranial traumas made it possible to substantially reduce the lethality among the patients and this pustified recommending it for wide clinical use.

Autonomic Nerve Block↗
PubMedDate not supplied

[Visceral pathology in severe cranio-cerebral injuries and its pathogenetic mechanisms].

Pathological conditions of the internal organs and their innervation apparatus, including the limbic cortex, reticular formation, vegetative nuclei of the vagus nerves and spinal cord, peripheral ganglia, and intramural plexuses, in severe craniocerebral trauma were studied by the clinico-physiological, clinico-morphological, and neurohistological methods. The innervation apparatuses of the organs were also studied in experiments with a purposeful effect exerted on the hypothalamus. Peculiarities in the manifestation of visceral pathology in diencephalic and mesencephalobulbar forms of brain lesions were established. Histological changes in the tissues of the organs and in the structures forming the efferent and afferent links of the visceral reflex arc are described. The dependence of the structural disturbances in the central and peripheral components of the vegetative nervous system on hypothalamic affection was confirmed experimentally. Their dynamics was studied. The data of the investigations are discussed from the standpoint of the results of a complex of purposeful surgical and nonoperative treatment of craniocerebral trauma and its complications. Particular attention is focussed on the role of the neuro-conduction mechanism in the development of pathological conditions of the organs. The tissue changes are considered to be neurodystrophic.

Animals↗
PubMedDate not supplied

[Late surgical results in severe craniocerebral trauma with foci of brain crushing].

The long-term results of treatment in 130 patients with foci of crushing in the cerebral hemispheres were studied in follow-up periods of 12 months to 12 years. It was established that compensation of the disturbed functions of the central nervous system and the extent of social-occupational adaptation are dependent on the time and volume of the operative intervention, the severity of brain damage, the patients' age, the type and degree of manifestation of the hypertensive-dislocation syndrome, and the application of a complex of intensive therapy measures. A higher level of social-occupational adaptation is achieved when the focus of brain destruction is removed within the bounds of the destruction zone and before the development of the dislocation syndrome.

Acute Disease↗